344746-40-3Relevant articles and documents
Allenes. Part 42. Nucleophilic Addition of Hydroxylamine to Allenic and Acetylenic Nitriles; Synthesis of 3-Alkyl-5-amino, 5-Amino-3-phenyl, and 3-Amino-5-phenyl-isoxazoles
Fomum, Z. Tanee,Asobo, P. Forsche,Landor, Stephen R.,Landor, Phyllis D.
, p. 1079 - 1083 (2007/10/02)
Hydroxylamine adds to allenic nitriles to give 3-alkyl-5-aminoisoxazoles in excellent yield.Hydroxyacetylenic nitriles similarly give 5-amino-3-(1-hydroxyalkyl)isoxazoles.Phenylpropynenitrile under varying conditions of temperature and solvent yields mainly 5-amino-3-phenylisoxazole with varying amounts of 3-amino-5-phenylisoxazole as a by-product.
