cas 34604-56-3, 3-hydroxy-monoethylglycinexylidide | Articles data ｜lookchem

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34604-56-3

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Simultaneous quantitation of lidocaine and its four metabolites by high-performance liquid chromatography: Application to studies on in vitro and in vivo metabolism of lidocaine in rats
A convenient and sensitive high-performance liquid chromatographic assay for the simultaneous quantitation of lidocaine and its four metabolites has been developed. The samples containing lidocaine and its metabolites were eluted from a microparticulate octadecylsilane column using a mobile phase of 0.1 M phosphate buffer (pH 3.0) containing 10% acetonitrile. This method was applied to studies on in vitro metabolism and in vivo pharmacokinetics of lidocaine in rats. Kinetic studies of in vitro microsomal metabolism of lidocaine indicated that the apparent K(m) and V(max) for aromatic hydroxylation were smaller than those for N-deethylation. Lineweaver-Burk plots of the N-deethylation of lidocaine and those of its two primary metabolites indicated that at least two isozymes are taking part in these reactions. In in vivo lidocaine pharmacokinetics, the area under the blood concentration-time curve for the monodeethylated product, ω-ethylamino-2,6-dimethylacetanilide (1), varied considerably depending on the route of administration.
Kawai,Fujita,Suzuki
p. 1219 - 1224
(2007/10/02)

Precursor-metabolite interaction in the metabolism of lidocaine
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Suzuki,Fujita,Kawai
p. 136 - 138
(2007/10/02)

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Chemical Properties

Boiling Point: 380.3°C at 760 mmHg
Flash Point:183.8°C
Density: 1.137g/cm³
Solubility:Acetonitrile (Slightly), Methanol (Slightly)
Storage Temp.:Refrigerator
Vapor Pressure: 2.51E-06mmHg at 25°C
PKA: 10.24±0.23(Predicted)
PSA: 64.85000
LogP: 2.59740

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