34604-56-3

Basic information

• Product Name: 3-hydroxy-monoethylglycinexylidide
• Synonyms: 3-hydroxy-monoethylglycinexylidide;3-Hydroxy-N-desethyl Lidocaine;2-(EthylaMino)-N-(3-hydroxy-2,6-diMethylphenyl)acetaMide;3-HydroxyMonoethylglycylxylidide;3-Hydroxy-N- (N-ethylglycyl)-2,6-xylidine;3-Hydroxy-ω-ethylaMino-2,6-diMethylacetanilide;SNX 483
• CAS NO: 34604-56-3
• Molecular Formula: C₁₂H₁₈N₂O₂
• Molecular Weight: 222.28352
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 34604-56-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 380.3°C at 760 mmHg
• Flash Point: 183.8°C
• Appearance: /
• Density: 1.137g/cm³
• Vapor Pressure: 2.51E-06mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Methanol (Slightly)
• PKA: 10.24±0.23(Predicted)
• CAS DataBase Reference: 3-hydroxy-monoethylglycinexylidide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-monoethylglycinexylidide(34604-56-3)
• EPA Substance Registry System: 3-hydroxy-monoethylglycinexylidide(34604-56-3)

Safety Data

• Hazardous Substances Data: 34604-56-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C12H18N2O2/c1-4-13-7-11(16)14-12-8(2)5-6-10(15)9(12)3/h5-6,13,15H,4,7H2,1-3H3,(H,14,16)

Upstream product

• 34604-55-2 3-Hydroxylidocaine 
• 137-58-6 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide 
• 7728-40-7 N-(2,6-dimethylphenyl)-2-ethylaminoacetamide 

Relevant articles and documents

Simultaneous quantitation of lidocaine and its four metabolites by high-performance liquid chromatography: Application to studies on in vitro and in vivo metabolism of lidocaine in rats

A convenient and sensitive high-performance liquid chromatographic assay for the simultaneous quantitation of lidocaine and its four metabolites has been developed. The samples containing lidocaine and its metabolites were eluted from a microparticulate octadecylsilane column using a mobile phase of 0.1 M phosphate buffer (pH 3.0) containing 10% acetonitrile. This method was applied to studies on in vitro metabolism and in vivo pharmacokinetics of lidocaine in rats. Kinetic studies of in vitro microsomal metabolism of lidocaine indicated that the apparent K(m) and V(max) for aromatic hydroxylation were smaller than those for N-deethylation. Lineweaver-Burk plots of the N-deethylation of lidocaine and those of its two primary metabolites indicated that at least two isozymes are taking part in these reactions. In in vivo lidocaine pharmacokinetics, the area under the blood concentration-time curve for the monodeethylated product, ω-ethylamino-2,6-dimethylacetanilide (1), varied considerably depending on the route of administration.