- Diaryl triazenes inhibit cytochrome P450 1A1 and 1B1 more strongly than aryl morpholino triazenes
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Several diaryl triazene derivatives were synthesized and tested for their ability to inhibit cytochrome P450 1A1 and 1B1 as a potential means to prevent and treat cancer. These compounds are more planar than their conformational flexible aryl morpholino t
- Moran, Rachel,Nakamura, Ryan,Isovitsch, Ralph,Iimoto, Devin
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supporting information
(2022/01/24)
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- Heck-Matsuda arylation of olefins through a bicatalytic approach: Improved procedures and rationalization
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The scope of the palladium-catalyzed Heck-Matsuda reaction, proceeding through the catalytic activation of anilines into the corresponding diazonium salts, has been considerably extended and is now working with deactivated electrophiles. Two different procedures, using catalytic amounts of both palladium and acid, have been optimized allowing the concept of bicatalysis to cover the complete electronic range of anilines. These environmentally friendly procedures proceed under very mild conditions, at room temperature in methanol, and only generate tert-butyl alcohol, water and nitrogen as by-products. Rationalization of reaction outcomes encountered in this work has been discussed with the support of computational studies.
- Oger, Nicolas,Le Callonnec, Francois,Jacquemin, Denis,Fouquet, Eric,Le Grognec, Erwan,Felpin, Francois-Xavier
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supporting information
p. 1065 - 1071
(2014/04/03)
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- Novel one-pot synthesis of thiophenols from related triazenes under mild conditions
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In this work, at first, triazenes were synthesized from primary aryl amines. Afterwards, triazenes were converted into the corresponding thiophenols in one-pot using sodium sulfide in acidic media, by in situ generation of diazonium counterion beside hydrogen sulfide as anionic sulfur nucleophile at room temperature. The procedure can be a convenient shortcut for the preparation of thiophenols from primary aryl amines. Georg Thieme Verlag Stuttgart · New York.
- Khazaei, Ardeshir,Kazem-Rostami, Masoud,Moosavi-Zare, Ahmadreza,Bayat, Mohammad,Saednia, Shahnaz
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experimental part
p. 1893 - 1896
(2012/09/22)
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- Pd-catalyzed C-H activation/C-N bond formation: A new route to 1-aryl-1H-benzotriazoles
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A method for the C-H activation of aryl triazene compounds followed by intramolecular amination is described. It involves the use of a catalytic amount of Pd(OAc)2 that efficiently effects the cyclization to provide 1-aryl-1H-benzotriazoles at moderate temperature.
- Kumar, Rapolu Kiran,Ali, Md Ashif,Punniyamurthy, Tharmalingam
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supporting information; experimental part
p. 2102 - 2105
(2011/06/25)
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- Nitrosation with Sodium Hexanitrocobaltate(III)
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Na3Co(NO2)6 has been investigated as a new reagent for the nitrosation of various substrates containing an amino functionality. Reactions took place in an aqueous solution of the reagent. The pH of the reaction mixture remained in the range 4.3-5. Thus, hydrazides were transformed to the corresponding acyl azides, and the reactions with arenesulfonyl hydrazines afforded arenesulfonyl azides. Treatment of aromatic amines with Na3Co(NO2)6 gave 1,3-diaryltriazenes in excellent yields; coupling of the initially formed diazo compound to the electron rich aromatic ring was also observed. Nitrosation of aliphatic amines was not possible due to complex formation with the reagent.
- Stefane, Bogdan,Kocevar, Marijan,Polanc, Slovenko
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p. 7165 - 7169
(2007/10/03)
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- REACTION OF ARYLDIAZONIUM SALTS WITH ACETONE OXIME
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The reaction of aryl diazonium salts containing electron-withdrawing substituents in the aromatic ring with acetone oxime leads to the formation of nitrogen-containing products instaed of the expected functional derivatives of 1-alkyl-3-aryltriazene 1-oxides.The structure of these products is a function of the number and chemical nature of the substituents in the diazo component. Keywords: aryldiazonium, triazene, triazene oxide, acetone oxime.
- Zlotin, S. G.,Prokshits, O. V.,Luk'yanov, O. A.
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p. 1495 - 1496
(2007/10/02)
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- SUBSTITUENT EFFECT ON SOLVOLYSIS OF 3-ACETYL-1,3-DIPHENYLTRIAZENES
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Eleven symmetrically disubstituted 3-acetyl-1,3-diphenyltriazenes have been synthetized by a new method.The solvolysis kinetics of title compounds has been measured in 20percent aqueous ethanol at several temperatures.The results are discussed from the point of view of temperature and substituent effects on the solvolysis rate constant of the 3-acetyl-1,3-diphenyltriazenes and conclusions are drawn about the reaction mechanism.
- Pytela, Oldrich,Pilny, Miroslav,Vecera, Miroslav
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p. 1173 - 1181
(2007/10/02)
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