- ONE-POT SYNTHESIS OF 2,2,4-TRICHLOROBUTANAL FROM TETRAHYDROFURAN
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Tetrahydrofuran was converted to 2,2,4-trichlorobutanal (1) in 60-73percent overall yield by isomerisation of intermediate 2,3,3-trichlorotetrahydrofuran (2) in the presence of 4-6percent (w:w) of aluminium trichloride at 100-140 deg C for 40-60 min.Zinc chloride and titanium tetrachloride were less effective as catalysts, while hydrogen chloride and paratoluenesulfonic acid were ineffective.
- Buyck, Laurent De,Menke, Niclas,Louagie, Jan
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p. 187 - 189
(2007/10/02)
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