- Direct C(sp3)-H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst
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A highly efficient, direct C(sp3)-H cyanation was developed under mild photocatalytic conditions. The method enabled the direct cyanation of various C(sp3)-H substrates with excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.
- Kim, Kunsoon,Lee, Seulchan,Hong, Soon Hyeok
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supporting information
p. 5501 - 5505
(2021/07/26)
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- Preparation method for 4-cyanocyclohexanone
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The invention provides a preparation method for 4-cyanocyclohexanone. The preparation method mainly overcomes the technical problems that conventional synthesis methods have high cost, great consumption of organic solvents and environmental pollution and
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Paragraph 0018-0022
(2018/08/28)
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- NOVEL COMPOUNDS FOR USE IN CANCER
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It relates to the compounds of formula (I), or their pharmaceutically or veterinary acceptable salts, or their stereoisomers or mixtures of stereoisomers, wherein X, L,R1, R 2, and R 3 are as defined herein, which are cancer cell differentiation inducing agents. It also relates to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of cancer, in particular by cell differentiation therapy.
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Page/Page column 46; 47
(2019/01/07)
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- QUINOLINE DERIVATIVES AS SMO INHIBITORS
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Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.
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Paragraph 0211; 0213
(2017/02/28)
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- Corresponding amine nitrile and method of manufacturing thereof
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The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.
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Paragraph 0143-0145; 0149; 0160; 0182; 0193; 0215; 0226
(2017/10/22)
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- PROCESS FOR PREPARING CYCLIC DIAMINES
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The present invention relates to a process for preparing a cyclic diamine, comprising the reaction of at least one cyclic alkene with a gas mixture (G) comprising dinitrogen monoxide to give at least one cyclic ketone and the subsequent conversion of the
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Page/Page column 26-27
(2010/06/15)
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- SUBSTITUTED ISOQUINOLINES AND ISOQUINOLINONES AS RHO KINASE INHIBITORS
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The invention relates to substituted isoquinoline and isoquinolinones of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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Page/Page column 156
(2010/01/30)
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- OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
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The present invention relates to compounds of formula (I) as defined herein that are melanocortin receptor agonists, to the preparation thereof and to the therapeutic use thereof in the treatment or prevention of a condition selected from obesity, diabetes and sexual dysfunctions that can affect both sexes, in the treatment of cardiovascular diseases, and also in anti-inflammatory uses or in the treatment of alcohol dependency.
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Page/Page column 36
(2010/11/27)
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- PROCESS FOR THE PREPARATION OF GEMINAL ((DIFLUOROCYCLOALKYL)METHYL) AMINES.
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The present invention relates to a process of preparing a compound of formula II, wherein R1, n, m and p are defined in the specification.
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Page/Page column 8-9
(2008/06/13)
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- 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
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The present invention is directed to 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives of formula (I), pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
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Page/Page column 116-117
(2008/06/13)
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- 2,3,4,9-TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
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The invention relates to novel tetrahydro-lH-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to patients.
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Page/Page column 50
(2008/06/13)
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- REMOTE OXIDATION OF CARBONYL COMPOUNDS IN Na2S2O8-NaCN: ESSENTIALLY SIMPLE APPROACH TO γ- AND δ-CYANODERIVATIVES
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Ketones and aldehydes are converted into γ- and δ-cyanoketones or cyanoacids in one-pot reaction of the remote oxidative cyanation with Na2S2O8-NaCN.
- Nikishin, Gennady I.,Troyansky, Emmanuil I.,Misintsev, Vasily V.,Molokanov, Alexander N.,Ogibin, Yuri N.
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p. 4215 - 4216
(2007/10/02)
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