34916-10-4

Basic information

• Product Name: CYCLOHEXANECARBONITRILE, 4-OXO-
• Synonyms: 4-OXOCYCLOHEXANECARBONITRILE;CYCLOHEXANECARBONITRILE, 4-OXO-;4-Isocyanocyclohexanone, 99%;4-cyano-cyclohexanone;4-oxocyclohexane-1-carbonitrile;4-OXOCYCLOHEXANECARBONITRILE(WXC05700)
• CAS NO: 34916-10-4
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.154
• Mol File: 34916-10-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 271℃
• Flash Point: 118℃
• Appearance: /
• Density: 1.05
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.465
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: CYCLOHEXANECARBONITRILE, 4-OXO-(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXANECARBONITRILE, 4-OXO-(34916-10-4)
• EPA Substance Registry System: CYCLOHEXANECARBONITRILE, 4-OXO-(34916-10-4)

Safety Data

• Hazardous Substances Data: 34916-10-4(Hazardous Substances Data)

Usage

Uses

4-Cyanocyclohexanone is used to prepare nicotinamides as PDE4 D isoenzymes inhibitors. It is also used as an anthranilic acid replacement in niacin receptor agonist.

InChI:InChI=1/C7H9NO/c8-5-6-1-3-7(9)4-2-6/h6H,1-4H2

Upstream product

• 100-45-8 3-cyclohexene-1-carbonitrile 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 108-94-1 cyclohexanone 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 112497-89-9 4-[(trimethylsilyl)oxy]cyclohex-3-ene-1-carbonitrile 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 
• 143-33-9 sodium cyanide 
• 58774-05-3 1-cyano-4-pyrrolidin-1-yl-cyclohex-3-enecarboxylic acid ethyl ester 

Downstream Products

• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 24056-34-6 4-hydroxycyclohexane-1-carbonitrile 
• 108236-58-4 4-(2,4-dinitro-phenylhydrazono)-cyclohexanecarboxylic acid 
• 791-28-6 Triphenylphosphine oxide 
• 97087-59-7 α-(3-aminocyclohexyl)methylamine 
• 13338-82-4 1-amino-4-(aminomethyl)cyclohexane 
• 1202009-17-3 4-((tert-butyldimethylsilyl)oxy)cyclohexanecarbonitrile 
• 1393903-49-5 4-((1SR,4SR)-4-((tert-butyldimethylsilyl)oxy)-1-cyanocyclohexyl)benzonitrile 
• 662114-39-8 4-(methylamino)cyclohexanecarbonitrile 
• 1204-85-9 4-(piperidin-1-yl)benzonitrile 
• 10282-30-1 4-pyrrolidin-1-yl-benzonitrile 
• 85872-87-3 4-(4-methylpiperidin-1-yl)-benzonitrile 
• 352018-90-7 1-(4-cyanophenyl)-piperidine-4-carboxylic acid ethyl ester 
• 344566-78-5 tert-butyl (1-(4-cyanophenyl)piperidin-4-yl)carbamate 

Relevant articles and documents

Direct C(sp3)-H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst

A highly efficient, direct C(sp3)-H cyanation was developed under mild photocatalytic conditions. The method enabled the direct cyanation of various C(sp3)-H substrates with excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.

Preparation method for 4-cyanocyclohexanone

The invention provides a preparation method for 4-cyanocyclohexanone. The preparation method mainly overcomes the technical problems that conventional synthesis methods have high cost, great consumption of organic solvents and environmental pollution and

QUINOLINE DERIVATIVES AS SMO INHIBITORS

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.