Copper-catalyzed oxidative coupling of carboxylic acids with formamides for the synthesis of α,β-unsaturated amides
A novel and efficient protocol for the synthesis of α,β- unsaturated amides has been developed using catalytic amount of Cu(OAc) 2 and TBHP as an available oxidant. Oxidative coupling of various unsaturated carboxylic acids with N,N-disubstituted formamides was examined to furnish the desired products in good yields.
Copper catalyzed cross-coupling reactions of carboxylic acids: An expedient route to amides, 5-substituted γ-lactams and α-acyloxy esters
A convenient and recyclable catalytic protocol for the synthesis of N,N-dimethyl substituted amides, 5-substituted γ-lactams and α-acyloxy ethers from carboxylic acids using CuO nanoparticles and TBHP is described.
Priyadarshini,Amal Joseph,Lakshmi Kantam
p. 18283 - 18287
(2013/10/21)
Condensation of aromatic aldehydes with VyV-dimethylacetamide in presence of dialkyl carbonates as dehydrating agents
Reactions of benzaldehydes with excess N,N- dimethylacetamide at 140 °C in the presence of diethyl carbonate as dehydrating agent and a base gave (E)-N,N- dimethylcinnamamides in good yields. If hydroxybenzal- dehydes are used as substrates the reaction is accompanied by alkylation. Springer-Verlag 2010.