34941-92-9

Basic information

• Product Name: 4-CHLORO-2-FLUOROPYRIDINE
• Synonyms: 4-CHLORO-2-FLUOROPYRIDINE;4-Chloro-2-fluoropyridine, 95+%
• CAS NO: 34941-92-9
• Molecular Formula: C₅H₃ClFN
• Molecular Weight: 131.54
• Product Categories: Pyridine series;Pyridines;Variety of halogenated heterocyclic series;Fluorine series
• Mol File: 34941-92-9.mol

Chemical Properties

• Boiling Point: 155.9 °C at 760 mmHg
• Flash Point: 48.1 °C
• Appearance: /Solid
• Density: 1.331 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.79±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-2-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-FLUOROPYRIDINE(34941-92-9)
• EPA Substance Registry System: 4-CHLORO-2-FLUOROPYRIDINE(34941-92-9)

Safety Data

• Hazardous Substances Data: 34941-92-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-2-fluoropyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique halogenated structure allows for the development of new drugs with improved therapeutic properties and targeted effects.
Used in Agrochemical Industry:
In the agrochemical sector, 4-chloro-2-fluoropyridine serves as a building block for the creation of agricultural chemicals, including pesticides and herbicides. Its incorporation into these compounds enhances their effectiveness in controlling pests and weeds, thereby contributing to increased crop yields and protection.
Used as an Intermediate in Organic Synthesis:
Beyond its applications in the pharmaceutical and agrochemical industries, 4-chloro-2-fluoropyridine is also utilized as an intermediate in the production of other organic compounds. Its versatile chemical structure facilitates its use in a broad range of organic synthesis processes, leading to the creation of novel and innovative chemical entities.

Upstream product

• 626-61-9 4-Chloropyridine 
• 19798-80-2 2-Amino-4-chloropyridine 

Downstream Products

• 856851-45-1 4-chloro-2-ethoxypyridine 
• 858351-87-8 6-(2-fluoropyridin-4-yl)-N-phenyl-4-pyrimidinamine 
• 364757-36-8 4-chloro-2-hydrazonepyridine 

Relevant articles and documents

CYANOTRIAZOLE COMPOUNDS AND USES THEREOF

The present invention provides a compound of Formula (I), or a pharmaceutically acceptable salt thereof: (I) wherein R1, R2, R3, and R4 are as defined herein. The present invention further provides therapeutic uses of these compounds, for example against human African typanosomiasis; pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE

The present invention provides compositions and methods for the selective C-H fluorination of nitrogen-containing heteroarenes with AgF2, which has previously been considered too reactive for practical, selective C-H fluorination. Fluorinated heteroarenes are prevalent in numerous pharmaceuticals, agrochemicals and materials. However, the reactions used to introduce fluorine into these molecules require pre-functionalized substrates or the use of F2 gas. The present invention provides a mild and general method for the C-H fluorination of nitrogen-containing heteroarene compounds to 2-fluoro-heteroarenes with commercially available AgF2. In various embodiments, these reactions occur at ambient temperature within one hour and occur with exclusive selectivity for fluorination at the 2-position. Exemplary reaction conditions are effective for fluorinating diazine heteroarenes to form a single fluorinated isomer.

Selective C-H fluorination of pyridines and diazines inspired by a classic amination reaction

Fluorinated heterocycles are prevalent in pharmaceuticals, agrochemicals, and materials. However, reactions that incorporate fluorine into heteroarenes are limited in scope and can be hazardous. We present a broadly applicable and safe method for the site-selective fluorination of a single carbon-hydrogen bond in pyridines and diazines using commercially available silver(II) fluoride. The reactions occur at ambient temperature within 1 hour with exclusive selectivity for fluorination adjacent to nitrogen. The mild conditions allow access to fluorinated derivatives of medicinally important compounds, as well as a range of 2-substituted pyridines prepared by subsequent nucleophilic displacement of fluoride. Mechanistic studies demonstrate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a broad range of nitrogen heterocycles.