- Preparation method of 2,4,5-triamino-6-hydroxypyrimidine sulfate and folic acid
-
The invention relates to a preparation method of 2,4,5-triamino-6-hydroxypyrimidine sulfate and folic acid. The preparation method comprises the following steps: enabling cyanoacetate and sodium nitrite to be subjected to reaction under the action of an organic solvent and/or an inorganic solvent and an acidic substance to obtain 2-oximidocyanoacetate; then, enabling the 2-oximidocyanoacetate andguanidine hydrochloride to be subjected to reaction under an alkaline condition to obtain 2,4-diamino-5-isonitroso-6-oxopyrimidine; enabling the 2,4-diamino-5-isonitroso-6-oxopyrimidine and hydrogen gas to be subjected to reaction under an alkaline condition by means of action of Pd/C to obtain 2,4,5-triamino-6-hydroxypyrimidine, and adding sulfuric acid to adjust the pH value to obtain 2,4,5-triamino-6-hydroxypyrimidine sulfate; and then, adding trichloroacetone and N-(4-aminobenzoyl)-L-glutamic acid to be subjected to reaction in a buffer solution under the action of a catalyst molecular sieve so as to obtain the folic acid. Based on the process route, the invention explores the influences of different reaction steps and refining conditions on the preparation route of 2,4,5-triamino-6-hydroxypyrimidine sulfate and the folic acid so as to reduce the wastewater pollution while increasing the yield.
- -
-
Paragraph 0088-0097
(2019/04/10)
-
- IKK-β as target to 2-acetyl-8-substituted guanine derivatives, application and its preparation method (by machine translation)
-
The present invention discloses a target IKK-β to 2-acetyl-8-substituted guanine derivatives, application and its preparation method, the compounds of the present invention to the A549 cell inhibitory activity, the increase of the density of the as to, its rate will also increase, however, the kind of compound, to b16-f10, H460 and U251 cell strain basic noec role, this kind of selectivity for inhibition of specific anti-tumor medicament as the same is of special significance. (by machine translation)
- -
-
Paragraph 0018
(2017/03/28)
-
