70-55-3Relevant articles and documents
Cellular AND Gates: Synergistic Recognition to Boost Selective Uptake of Polymeric Nanoassemblies
Fernandez, Ann,Gao, Jingjing,Thayumanavan, S.,Wu, Peidong,Zhuang, Jiaming
, p. 10456 - 10460 (2020)
The development of nanoparticle-based biomedical applications has been hampered due to undesired off-target effects. Herein, we outline a cellular AND gate to enhance uptake selectivity, in which a nanoassembly–cell interaction is turned on, only in the concurrent presence of two different protein functions, an enzymatic reaction (alkaline phosphatase, ALP) and a ligand–protein (carbonic anhydrase IX, CA IX) binding event. Selective uptake of nanoassemblies was observed in cells that overexpress both of these proteins (unicellular AND gate). Interestingly, selective uptake can also be achieved in CA IX overexpressed cells, when cocultured with ALP overexpressed cells, where the nanoassembly presumably acts as a mediator for cell–cell communication (bicellular AND gate). This logic-gated cellular uptake could find use in applications such as tumor imaging or theranostics.
Kinetics and Mechanism of Oxidation of L-Threonine in Acid Media by Sodium N-Chloro-p-toluenesulfonamide
Mahadevappa, D. S.,Rangappa, K. S.,Gowda, N. M. M.,Gowda, B. Thimme
, p. 3651 - 3658 (1981)
Kinetics of oxidation of L-threonine in the presence of HCl, HClO4, and H2SO4 by chloramine-T (CAT) has been investigated at 35 deg C.The reactions follow identical kinetics in all acids, being first order in CAT, fractional order in substrate and Cl- ion, and of an inverse fractional order in +>.Variation of ionic strength and addition of the reaction product, p-toluenesulfonamide, or the ions SO42- and ClO4- had no effect on the rate.Decrease of dielectric constant of the medium by adding methanol decreased the rate.The solvent isotope effect was studied by using heavy water.The reactions were studied at different temperatures, and activation parameters have been computed.Mechanisms proposed and the derived rate laws are consistent with the observed kinetics.The rate constants predicted by the derived rate laws, as the concentrations of H+ ion, substrate, and Cl- ion change, are in excellent agreement with the observed rate constants, thus further justifying these rate laws and hence the proposed mechanistic schemes.
Synthesis of 8-Alkoxy-5 H-isochromeno[3,4- c]isoquinolines and 1-Alkoxy-4-arylisoquinolin-3-ols through Rh(III)-Catalyzed C-H Functionalization of Benzimidates with 4-Diazoisochroman-3-imines and 4-Diazoisoquinolin-3-ones
Li, Zhenmin,Lu, Ping,Wang, Yanguang,Xie, Jianwei
, p. 5525 - 5535 (2020)
Rh(III)-catalyzed C-H activation/annulation of benzimidates with 4-diazoisochroman-3-imines furnished 8-alkoxy-5H-isochromeno[3,4-c]isoquinolines in moderate to excellent yields with a broad range of substrate scope. The reaction was carried out under mild reaction conditions and could be scaled up with practical usage. Similar reaction between benzimidates and 4-diazoisoquinolin-3-ones provided 1-alkoxy-4-arylisoquinolin-3-ols in excellent yields. Moreover, the synthesized products could be conveniently transformed to the corresponding heterocycles with a 1,8-naphthyridinone or isochromenopyridinone core, which are privileged structures in medicinal chemistry.
Kinetics and Mechanism of the Oxidation of Hypophospite with N-Chlorotoluene-p-sulphonamide (Chloramine T) catalysed by Osmium(VIII) in Alkaline Solution
Hussain, Juzar,Mishra, Som Kant,Sharma, Preen Dutt
, p. 89 - 92 (1991)
The kinetics of osmium(VIII)-catalysed oxidation of hypophosphite, H2PO2-, with chloramine T (cat, N-chlorotoluene-p-sulphamide) was studied by estimating the latter iodometrically.The rate law (i) holds for -> = 0.02-0.142, H2PO
Anisole alkylation with N-arenesulfonylimines of dichloro(phenyl)acetaldehyde and derivatives thereof
Drozdova,Mirskova
, p. 819 - 821 (2001)
N-[1-4-Methoxyphenyl-2-phenyl-2,2-dichloroethyl]arenesulfonamides are formed in reaction of N-(2-phenyl-2,2-dichloroethylidene)-4-chlorobenzenesulfonamide and N-(2-phenyl-2,2-dichloroethylidene)-4-methylbenzenesulfonamide with anisole catalyzed by boron t
The Reaction of Thiocumulenes with Fulvene
Saito, Takao,Musashi, Teruhiko,Motoki, Shinichi
, p. 3377 - 3378 (1980)
S-(9-Fluorenylidene)-N-(p-tolylsulfonyl)-sulfimide and bis(p-tolylsulfonyl)sulfur diimide reacted as 1,3-dipoles with fulvenes to form (2+3)cycloadducts.
Structural, vibrational spectra and normal coordinate analysis for two tautomers of 4(5)-(2′-furyl)-imidazole
Ledesma,Zinczuk,Gonzalez, J.J. Lopez,Altabef, A. Ben,Brandan
, p. 587 - 597 (2010)
We have synthesized both the 4 and 5 tautomeric forms of 4(5)-(2′-furyl)-imidazole (1) and investigated their molecular vibrations by infrared and Raman spectroscopies as well as by calculation based on the density functional theory (DFT) approach. Examination of the temperature dependence of IR intensity revealed the band characteristics of the 4 and 5 tautomersof(1).Comparisonofexperimentalandcalculatedchemicalshiftsinnucl earmagneticresonance(NMR)spectroscopy was made in order to identify the two tautomeric forms. The assignment of vibrational normal modes was performed, and the forcefieldobtainedreproduced theexperimentalvibrationalwavenumbers with a root mean-squaredeviation (RMSD)value of ca. 13 cm-1 for both tautomers. The natural bond orbital (NBO) study reveals the characteristics of the electronic delocalization of the two tautomeric structures.
Synthesis of cyclic sulfonamides via Pd-catalyzed intramolecular coupling reaction: An expedient approach to polycyclic sultams
Majumdar,Mondal, Shovan,De, Nirupam
, p. 2851 - 2855 (2008)
A divergent synthetic approach to polycyclic sultams utilizing intramolecular ligand-free intramolecular coupling reaction is described. Georg Thieme Verlag Stuttgart.
Formation and Isolation of the Disulphide Dication of 1,5-Dithiacyclo-octane in the Reactions of the Corresponding S-Oxide and S-(N-tosylimide) in Concentrated Sulphuric Acid
Furukawa, Naomichi,Kawada, Akira,Kawai, Tsutomu
, p. 1151 - 1152 (1984)
The disulphide dication of 1,5-dithiacyclo-octane was generated in the reaction of the corresponding S-oxide and S-(N-tosylimide) with conc.H2SO4 and isolated in crystalline form.
Michael additions of oxygen and sulfur nucleophiles to 3,4-Di-t-butyl-1-[(p-tolyl)sulfonylimino]-1,1-dihydrothiophene. A comparison study with 3,4-Di-t-butylthiophene 1-oxide and 1,1-dioxide
Otani, Takashi,Sugihara, Yoshiaki,Ishii, Akihiko,Nakayama, Juzo
, p. 744 - 745 (2000)
The reactions of 3,4-di-t-butyl-1-[(p-tolyl)sulfonylimino]-1,1-dihydrothiophene with RONa and RSNa furnished 2-alkoxy-and 2-alkylthio-substituted thiophenes, respectively, through Michael adduct formation. The reaction of 3,4-di-t-butylthiophene 1-oxide with RSNa gave 1,6-Michael adducts, whereas the corresponding reaction of 3,4-di-t-butylthiophene 1,1-dioxide produced a mixture of 1,4-and 1,6-adducts.
