This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.
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Page/Page column 105-106
(2008/06/13)
Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants
Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.
Shiozawa,Narita,Izumi,Kurashige,Sakitama,Ishikawa
p. 85 - 94
(2007/10/02)
Derivatives of an aminoketone
A new class of aminoketone derivatives according to the formula: STR1 and certain propiophenone derivatives in particular, corresponding to the formula: STR2 having central muscle relaxant activity.
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(2008/06/13)
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