351065-79-7

Basic information

• Product Name: 2,5-DIMETHOXY-THIOBENZAMIDE
• Synonyms: 2,5-DIMETHOXY-THIOBENZAMIDE;Benzenecarbothioamide, 2,5-dimethoxy- (9CI)
• CAS NO: 351065-79-7
• Molecular Formula: C9H11NO2S
• Molecular Weight: 197.25
• Product Categories: THIOAMIDE
• Mol File: 351065-79-7.mol

Chemical Properties

• Boiling Point: 354.7 °C at 760 mmHg
• Flash Point: 168.3 °C
• Appearance: /
• Density: 1.202 g/cm³
• Vapor Pressure: 3.3E-05mmHg at 25°C
• Refractive Index: 1.595
• PKA: 12.43±0.29(Predicted)
• CAS DataBase Reference: 2,5-DIMETHOXY-THIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXY-THIOBENZAMIDE(351065-79-7)
• EPA Substance Registry System: 2,5-DIMETHOXY-THIOBENZAMIDE(351065-79-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-43-22
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 351065-79-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-DIMETHOXY-THIOBENZAMIDE is used as an intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows it to be a key component in the creation of various medicinal compounds, enhancing their therapeutic effects and properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-DIMETHOXY-THIOBENZAMIDE serves as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its incorporation into these products can improve their effectiveness in controlling pests and weeds, thus contributing to increased crop yields and agricultural productivity.
Used in Organic Compounds Synthesis:
2,5-DIMETHOXY-THIOBENZAMIDE is also utilized as an intermediate in the synthesis of other organic compounds. Its versatile structure makes it a valuable building block for the creation of a wide range of organic molecules, which can be used in various applications, including materials science, chemical research, and the development of new technologies.

InChI:InChI=1/C9H11NO2S/c1-11-6-3-4-8(12-2)7(5-6)9(10)13/h3-5H,1-2H3,(H2,10,13)

Upstream product

• 42020-21-3 2,5-dimethoxybenzamide 
• 2785-98-0 2,5-dimethoxybenzoic acid 
• 17918-14-8 2,5-dimethoxybenzoyl chloride 

Relevant articles and documents

Thiazole derivative and synthesis method thereof

The invention belongs to the technical field of organic synthesis, particularly relates to a thiazole derivative and a synthetic method thereof, and particularly relates to a thiazole derivative (Z)-4-((2-(2-(2-(2,5-dimethoxyphenyl)-thiazole-5-yl)-ethylimino)(phenyl)methyl)-1,3-benzenediol and a synthetic method thereof. The synthesis method provided by the invention comprises the following steps:by taking 2,5-dimethoxybenzamide and ethyl 2-chloroacetate as raw materials, carrying out six reaction steps of carbonyl sulfide reaction, substitution, cyclization, substitution, chlorination, cyanidation, amidation, hydrolysis and substitution reaction to prepare the (Z)-4-((2-(2-(2-(2,5-dimethoxyphenyl)-thiazole-5-yl)-ethylimino)(phenyl)methyl)-1,3-benzenediol. According to the invention, an efficient synthesis method is provided for the synthesis of the thiazole derivative.

3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents

Small molecules with oxathiazol-2-one moiety were recently reported as potent inhibitors of Mycobacterium bovis var. bacilli Calmette-Guérin (BCG), among which HT1171 was the most potent and selective proteasome inhibitor. Herein we synthesized a series of novel compounds by bioisosteric replacement of the oxathiazol-2-one ring with 3H-1,2,4-dithiazol-3-one, and also fifteen 1,3,4-oxathiazol-2-one molecules in order for potency comparison and structure-activity relationship elucidation since their antibacterial effects on the virulent strains were not evaluated before. All the compounds were assessed for antitubercular activities on the virulent H37Rv strain by a serial dilution method. Among the tested compounds, 3H-1,2,4-dithiazol-3-one compound 4n was found to be the most active with a lowest MIC90 value of 1 μg/mL. Furthermore, the cytotoxicities of all the compounds against normal human liver cell line L02 were determined by an MTT method. Compound 4n displayed a lower inhibitory ratio than HT1171 at the concentration of 100 μM, indicating its better safety profile.