352032-26-9

Basic information

• Product Name: 3-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL
• Synonyms: 3-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL
• CAS NO: 352032-26-9
• Molecular Formula: C₁₄H₁₁F₃O
• Molecular Weight: 252.23
• Mol File: 352032-26-9.mol

Chemical Properties

• Boiling Point: 305.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL(352032-26-9)
• EPA Substance Registry System: 3-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL(352032-26-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 352032-26-9(Hazardous Substances Data)

Usage

Molecular Weight

244.22 g/mol

Chemical Classification

Biphenyl derivative

Substituents

Trifluoromethyl group and methoxy group on two phenyl rings

Common Uses

Building block in synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Value

Valuable intermediate in production of various organic compounds

Versatility

Widely used in research and industrial applications

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 122439-11-6 tributyl(3-methoxyphenyl)stannane 
• 2398-37-0 3-methoxyphenyl bromide 
• 766-85-8 3-methoxy-1-iodobenzene 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 10365-98-7 3-methoxyphenylboronic acid 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 

Downstream Products

• 365426-92-2 3'-(trifluoromethyl)-[1,1'-biphenyl]-3-ol 

Relevant articles and documents

N-heterocyclic carbene coordinated heterogeneous Pd nanoparticles as catalysts for suzuki-miyaura coupling

Palladium nanoparticle (Pd NP) catalysts immobilized in a polymer with an N-heterocyclic carbene (NHC) moiety (PICBNHC-Pd) have been developed, wherein the NHC moiety plays dual roles as a crosslinker and a ligand to activate the Pd NPs. The presence of both Pd NPs and NHC was confirmed by STEM/EDS and SR-MAS NMR analyses, respectively. This PICB-NHC-Pd catalyst showed excellent activity in the Suzuki-Miyaura coupling reaction without leaching of Pd. Excellent results were obtained in gram-scale synthesis, and catalyst recovery/reuse experiments were completed without loss of catalyst activity.

Efficient one-pot cross-coupling of two aryl halides by stannylation/stille reaction in water under microwave irradiation

A simple and highly efficient one-pot approach has been developed for the Pd(PPh3)4-catalyzed cross-coupling of two different aryl or heteroaryl bromides/iodides. This method involves the combined use of microwave irradiation and water as a single solvent to achieve sequential stannylation and Stille cross-coupling reactions, which allows rapid access to a wide variety of biaryls in good to high yields. Furthermore, utilizing this step-economical protocol, 2,5-dibromopyridine was iteratively diarylated and the Boscalid intermediate was also synthesized in a one-pot manner. Copyright

Aminoborylation/Suzuki-Miyaura tandem cross coupling of aryl iodides as efficient and selective synthesis of unsymmetrical biaryls

Sequential borylation of a first aryl iodide using a dialkylaminoborane followed by a Suzuki-Miyaura cross coupling of second aryl iodide ended up with an efficient, selective and practical synthesis of unsymmetrical biaryls. This tandem coupling shows a wide range of applicability.

Cyclohexylcarbamic acid 3′- or 4′-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: Synthesis, quantitative structure-activity relationships, and molecular modeling studies

Fatty acid amide hydrolase (FAAH) is a promising target for modulating endocannabinoid and fatty acid ethanolamide signaling, which may have important therapeutic potential. We recently described a new class of O-arylcarbamate inhibitors of FAAH, includin

Biaryl Synthesis from Two Different Aryl Halides with Tri(2-furyl)germane

(Matrix Presented) The coupling reaction of germanium compounds with aryl halides has been developed. The Pd(0)-catalyzed reaction of aryl halides with tri(2-furyl)germane provides aryltri(2-furyl)germanes in good yield. The cross-coupling reaction of aryltri(2-furyl)germanes with aryl halides is acheived. This allows facile synthesis of unsymmetrical biaryls from two different aryl halides.

Application of the 'resin-capture-release' methodology to macrocyclisation via intramolecular Suzuki-Miyaura coupling

Aryl boronic acids can be trapped by an ammonium hydroxide-form Dowex Ion Exchangers resin (D-OH-) leading to polymer-ionically bound borates and cyclized, when properly designed, into macroheterocycles under Suzuki-Miyaura coupling conditions.