Synthesis of substituted uracils by the reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles under focused microwave irradiation
Under microwave irradiation, the nucleophilic substitution reactions of halouracils with selenium, sulfur, oxygen and nitrogen nucleophiles was complete within several minutes with yields up to 99%. The method using microwave irradiation is superior to th
Reductive Debromination and Coupling Reaction in the Thermolysis of 5-Bromouracils in N,N-Dialkylamides. Cleavage of the C(5)-Bromine bond by an Initial Electron-transfer Process
Thermolysis of various 5-bromouracils (1) in N,N-dialkylamides results in the formation of methylenebisuracils (2) and reductive debrominated products (3) via cleavage of the C(5)-Br bond; the latter involves a one-electron transfer process.The product distribution between (2) and (3) depends upon the nature of substituents in the uracil ring.