352637-09-3Relevant articles and documents
NOVEL IMMUNE ACTIVATORS: SUBSTITUTE 4-AMINOQUINAZOLINES
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Paragraph 0225; 0206, (2015/05/26)
Provided herein are compounds and methods for modulating an immune response in a subject in need thereof. Further provided herein are compounds and methods for modulating a toll-like receptor protein.
Discovery of substituted 4-aminoquinazolines as selective Toll-like receptor 4 ligands
Nour, Afshin,Hayashi, Tomoko,Chan, Michael,Yao, Shiyin,Tawatao, Rommel I.,Crain, Brian,Tsigelny, Igor F.,Kouznetsova, Valentina L.,Ahmadiiveli, Alast,Messer, Karen,Pu, Minya,Corr, Maripat,Carson, Dennis A.,Cottam, Howard B.
, p. 4931 - 4938 (2014/12/11)
The Toll-like receptors (TLRs) are critical components of the innate immune system that regulate immune recognition in part through NF-κB activation. A human cell-based high throughput screen (HTS) revealed substituted 4-aminoquinazolines to be small mole