353260-19-2Relevant articles and documents
4-Aminopyrimidine libraries from the Ugi-Smiles reaction of thiouracil
Sidhoum, Madjid Ait,El Ka?m, Laurent,Grimaud, Laurence
, p. 5222 - 5231 (2018/05/04)
The Ugi-Smiles reaction of S-benzyl thiouracil have been exploited in several three-step sequences for the preparation of aminopyrimidine libraries with high diversity. After the 4-component coupling, oxidation of the thioether to sulfone is followed by displacement of the latter by various carbon-centered nucleophiles (cyanide, malonate, boronic acids) or amines. The efficiency of the whole sequence was further demonstrated with one-pot procedures.
Ugi-smiles coupling of thiouracil derivatives towards 2,4-diamino pyrimidines
Sidhoum, Madjid Ait,Ka?m, Laurent El,Grimaud, Laurence
supporting information; experimental part, p. 632 - 636 (2012/04/11)
Diaminopyrimidines could be synthesized via a multicomponent coupling starting from S-alkyl thiouracil derivatives. The synthetic strategy based upon an Ugi-Smiles coupling, and subsequent oxidation of the adducts affords a versatile platform for the prep