456-41-7

Basic information

• Product Name: 3-Fluorobenzyl bromide
• Synonyms: ALPHA-BROMO-M-FLUOROTOLUENE;ALPHA-BROMO-3-FLUOROTOLUENE;3-FLUOROBENZYL BROMIDE;M-FLUOROBENZYL BROMIDE;1-(bromomethyl)-3-fluoro-benzen;1-(Bromomethyl)-3-fluorobenzene;Benzene, 1-(bromomethyl)-3-fluoro-;meta-Fluorobenzyl bromide
• CAS NO: 456-41-7
• Molecular Formula: C₇H₆BrF
• Molecular Weight: 189.02
• EINECS: 207-263-2
• Product Categories: Fluoro-contained benzyl bromide series;Fluorobenzene;Benzyl;Fluorinated benzene series
• Mol File: 456-41-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 88 °C20 mm Hg(lit.)
• Flash Point: 143 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.541 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.548mmHg at 25°C
• Refractive Index: n20/D 1.546(lit.)
• Storage Temp.: 0-6°C
• Sensitive: Lachrymatory
• BRN: 636503
• CAS DataBase Reference: 3-Fluorobenzyl bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluorobenzyl bromide(456-41-7)
• EPA Substance Registry System: 3-Fluorobenzyl bromide(456-41-7)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 23-26-27-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 456-41-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

Uses

3-Fluorobenzyl Bromide is a substituted benzyl bromide used as a reagent in the preparation of wide range of biologically active compounds such as antidiabetic drugs, anti-virals and anti-cancer agen ts.

InChI:InChI=1/C7H6BrF/c8-5-6-2-1-3-7(9)4-6/h1-4H,5H2

Upstream product

• 456-42-8 m-fluorobenzyl chloride 
• 456-48-4 3-Fluorobenzaldehyde 
• 108-44-1 1-amino-3-methylbenzene 
• 506-68-3 bromocyane 
• 351-25-7 benzyl-(3-fluoro-benzyl)-sulfide 
• 28490-56-4 1-fluoro-3-(iodomethyl)benzene 
• 456-47-3 3-fluoro-benzenemethanol 
• 352-70-5 m-Fluorotoluene 

Downstream Products

• 358-48-5 benzyl-(3-fluoro-benzyl)-malonic acid diethyl ester 
• 501-00-8 3-fluorophenylacetonitrile 
• 71324-00-0 (3-fluoro-benzyl)-trimethyl-ammonium; bromide 
• 2267-30-3 3-fluoro-benzyl fluoride 
• 455-34-5 1-(dibromomethyl)-3-fluorobenzene 
• 3762-40-1 Dimethyl-<3-fluor-benzyl>-carbinol 
• 156868-83-6 3-(3-fluorophenyl)propan-1-ol 
• 1737-19-5 (3-fluorophenyl)acetone 
• 189182-04-5 3,12-Bis-(3-methyl-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester 
• 189182-06-7 3,12-Bis-(3-fluoro-benzyl)-3,7,12,18-tetraaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-triene-7-carboxylic acid tert-butyl ester 
• 352-70-5 m-Fluorotoluene 
• 351-22-4 1,2-bis(3-fluorophenyl)ethane 
• 204196-34-9 {2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-methyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 
• 204196-41-8 {2-[(6-{[(3-Fluoro-benzyl)-(3-trifluoromethyl-benzyl)-amino]-methyl}-pyridin-2-ylmethyl)-(3-trifluoromethyl-benzyl)-amino]-ethyl}-(3-hydroxy-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis, Docking, and Biological activities of novel Metacetamol embedded [1,2,3]-triazole derivatives

ERα controls the breast tissue development and progression of breast cancer. In our search for novel compounds to target Estrogen Receptor Alpha Ligand-Binding Domain, we identified “N-(3-((1H-1,2,3-triazol-4-yl)methoxy)phenyl)acetamide” derivatives as lead compounds. The Docking studies indicated good docking score for Metacetamol derivatives when docked into the 1XP6. A series of metacetamol derivatives have been synthesized, characterized and evaluated for cytotoxicity, anti bacterial and anti oxidant activities. Among the tested twelve hybrid compounds, “7a, 7g, 7h and 7i” derivatives showed promising cytotoxicity with IC50 value of 50 value of 30 μM, whereas Compounds “7a, 7b, 7c, 7d, 7g, 7j, 7k and 7l” showed moderate anti bacterial activity with the MIC value of 300 μM.

One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization

A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.

Fluorobenzamides and uses thereof

The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.