- BICYCLIC IMIDAZOLIDINONES AS POTENTIAL ANTIBIOTICS
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The bicyclic imidazolidinones 5 topologically related to the penicillin family, are susceptible to form a stable carbamate with serine-D,D-peptidases.A series of N-7 acylated or sulfonylated (2R,5R)-3,3-dimethyl-8-oxo-4-thia-7,1-diazabicyclooctane-2-carboxylates 12-21 have been prepared.None of these novel penicillin analogs exhibited antibacterial activity.
- Marchand-Brynaert, Jacqueline,Vanlierde, Huguette,Ghosez, Leon
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p. 1081 - 1094
(2007/10/02)
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- 6α, β-Substituted penicillin derivatives
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Novel 6-methoxy and 6-thioalkyl-6-acylamido-penicillanic acids and their non-toxic pharmaceutically-acceptable salts, esters and amides which are useful as antibiotics. The products are prepared by treating an ester of 6-substituted-6-aminopenicillanic acid with an acylating agent followed by removal of the ester group. Also disclosed are novel intermediates.
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