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CAS

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354813-19-7

Balicatib is a pharmaceutical compound that acts as a potent inhibitor of Cathepsin K (Cat K), a lysosomal cysteine protease enzyme. It is designed to target and regulate the activity of Cat K, which plays a significant role in bone resorption and remodeling processes. By inhibiting Cat K, Balicatib aims to provide a therapeutic intervention for the treatment of osteoporosis and potentially other bone-related disorders.

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  • 354813-19-7 Structure

  • Basic information

    1. Product Name: Balicatib
    2. Synonyms: Balicatib;Balicatib, AAE-581;Balicatib N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide;N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide Balicatib(AAE-581);Balicatib, >=98%;AAE-581
    3. CAS NO:354813-19-7
    4. Molecular Formula: C23H33N5O2
    5. Molecular Weight: 411.55
    6. EINECS: 200-256-5
    7. Product Categories: Inhibitors
    8. Mol File: 354813-19-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 687.4±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.19±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.23±0.20(Predicted)
    10. CAS DataBase Reference: Balicatib(CAS DataBase Reference)
    11. NIST Chemistry Reference: Balicatib(354813-19-7)
    12. EPA Substance Registry System: Balicatib(354813-19-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 354813-19-7(Hazardous Substances Data)

354813-19-7 Usage

Uses

Used in Pharmaceutical Industry:
Balicatib is used as a therapeutic agent for the treatment of osteoporosis. Its application is based on its ability to inhibit Cathepsin K, a key enzyme involved in bone resorption. By reducing the activity of Cat K, Balicatib can help slow down bone loss and improve bone density, offering a potential treatment option for patients suffering from osteoporosis.
Additionally, Balicatib's inhibitory effect on Cathepsin K may also have implications for other bone-related conditions and diseases, suggesting potential applications in broader therapeutic areas within the pharmaceutical industry. However, further research and clinical trials would be necessary to explore and validate these additional uses.

Check Digit Verification of cas no

The CAS Registry Mumber 354813-19-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,4,8,1 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 354813-19:
(8*3)+(7*5)+(6*4)+(5*8)+(4*1)+(3*3)+(2*1)+(1*9)=147
147 % 10 = 7
So 354813-19-7 is a valid CAS Registry Number.

354813-19-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Balicatib

1.2 Other means of identification

Product number -
Other names AAE 581

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:354813-19-7 SDS

354813-19-7Downstream Products

354813-19-7Relevant articles and documents

Dipeptide nitrile cathepsin K inhibitors

-

, (2008/06/13)

Dipeptide nitrile Cathepsin K inhibitors of formula I, and pharmaceutically acceptable salts or esters thereof In which R1 and R2 are independently H or C1-C7lower alkyl, or R1 and R2 toget

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