- Preparation method of buflomedil hydrochloride
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The invention relates to the field of medicine production, in particular to a preparation method of buflomedil hydrochloride. The preparation method comprises the steps as follows: synthesis of 1-pyrrolidyl methyl butyrate: 68.3 g of methyl 4-chlorobutyrate, 82.8 g of anhydrous potassium carbonate, 0.2 g of potassium iodide, 39.1 g of pyrrolidine and 500 mL of acetone are put in a dry reaction bottle and heated for a reflux reaction for 3 h, a reaction solution is cooled to the room temperature, potassium carbonate is filtered out, filtrate is dried under reduced pressure, 500 mL of dichloromethane is added and dissolved, an organic phase is washed with a saturated ammonium chloride aqueous solution until the pH is 7-8, the organic phase is dried with anhydrous magnesium sulfate and then concentrated for removal of dichloromethane, a concentrate is obtained and subjected to distillation under reduced pressure, a fraction at 107-109 DEG C is collected, and 80.1 g of 1-pyrrolidyl methylbutyrate is obtained. The process is simple, the reaction is safe, the synthesis route is short, raw materials are easy to obtain, the condition is mild, and the cost is lower.
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Paragraph 0006
(2018/04/02)
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