Welcome to LookChem.com Sign In|Join Free

CAS

  • or

35543-24-9

Post Buying Request

35543-24-9 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

35543-24-9 Usage

Description

Buflomedil hydrochloride is a vasoactive drug with a variety of actions. It is an alpha-adrenoceptor antagonist and a weak calcium channel blocker. It inhibits platelet aggregation and improves erythrocyte deformability. However, its mechanism of action in peripheral vascular disease is not known.Buflomedil has generally been well tolerated by most patients in clinical trials. The most frequently reported adverse effects include flushing, headache, vertigo, gas-trointestinal discomfort, and dizziness. These rarely require drug withdrawal. In controlled trials, adverse effects have occurred in 20% of patients assigned to buflomedil and 18% of those assigned to placebo; only gastrointestinal discomfort occurred more frequently in buflomedil-treated patients (3.4 versus 2%)

Uses

Different sources of media describe the Uses of 35543-24-9 differently. You can refer to the following data:
1. Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases
2. 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride is used as an vasodilator (peripheral).

Biological Activity

Buflomedil is a non-selective antagonist of α-adrenergic receptors (α-ARs) and vasoactive compound.It binds to rat α1A- and α1B-ARs (Kis = 4.06 and 6.84 μM, respectively) and human platelet α2-ARs (IC50 = 1 μM) in radioligand binding assays.Buflomedil (0.06-60 μM) inhibits contraction of isolated canine saphenous veins induced by phenylephrine, clonidine, sympathetic nerve stimulation, or norepinephrine.It inhibits ADP-, collagen-, or epinephrine-induced aggregation of isolated human platelets when used at a concentration of 100 μM.Buflomedil (10 mg/kg) reduces hippocampal neuronal cell death in a rat model of carotid clamping-induced ischemia-reperfusion injury.https://www.caymanchem.com

Synthesis

The target compound of buflomedil hydrochloride was synthesized from methyl 4-chlorobutyrate by condensation with pyrrolidine,then by hydrolysis,acylation,Fridel-crafts alkylation and salt formation.The structure of the target compound was confirmed by IR,1H-NMR and MS.The synthetic procedure is suitable for industrial production for the advantage of avaible materials,shorter routes,convenient operation and lower cost,the overall yield is improved from the reported 70% to 75.7%. https://www.semanticscholar.org

Overdosage

Buflomedil is generally considered to be innocuous at therapeutic dosages. Acute toxicity is due to accidental or intentional overdosage. Overdosage causes generalized seizures and cardiac conduction abnormalities, eventually leading to cardiac arrest (SEDA-21, 215).Meyler's Side Effects of Cardiovascular Drugs

Chemical Properties

White Solid

Originator

Fonzylane,Lafon,France,1976

Manufacturing Process

Introduce 33.6 g (0.2 mol) of 1,3,5-trimethoxybenzene and 100 ml of chlorobenzene into a 500 ml three-neck flask with stirrer, hydrochloric acid bubbler and condenser. Stir to dissolve and add 27.7 g of 4- pyrrolidinobutyronitrile (from 4-chlorobutyronitrile and pyrrolidine). Cool to about 15°-20°C and bubble hydrochloric acid gas in for 4 hours. Cool to about 5°C and add 200 cm3 of water. Stir. Decant the aqueous layer, wash again with 150 cm3 of water. Combine the aqueous layers, drive off the traces of chlorobenzene by distilling 150 cm3 of water, and heat under reflux for one hour. Cool and render alkaline by means of 60 ml of sodium hydroxide solution of 36° Baume. Extract twice with 100 ml of ether. Wash the ether with 100 ml of water. Dry the ether over sodium sulfate and slowly run in 50 ml of 5N hydrogen chloride solution in ether, at the boil. Cool in ice. Filter, wash with ether and dry in a vacuum oven. 33.6 g of crude product are obtained. Recrystallize from 200 ml of isopropanol in the presence of 3 SA carbon black. Filter. Wash and dry in a vacuum oven. 26.9 g of a white, crystalline water-soluble powder are obtained. Yield: 39.2%. Instantaneous melting point: 192°-193°C.

Therapeutic Function

Vasodilator

Check Digit Verification of cas no

The CAS Registry Mumber 35543-24-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,5,4 and 3 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 35543-24:
(7*3)+(6*5)+(5*5)+(4*4)+(3*3)+(2*2)+(1*4)=109
109 % 10 = 9
So 35543-24-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H26O4.ClH/c1-20-14-11-16(21-2)18(17(12-14)22-3)15(19)10-6-9-13-7-4-5-8-13;/h11-13H,4-10H2,1-3H3;1H

35543-24-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (B3647)  Buflomedil Hydrochloride  >98.0%(HPLC)(T)

  • 35543-24-9

  • 1g

  • 290.00CNY

  • Detail
  • TCI America

  • (B3647)  Buflomedil Hydrochloride  >98.0%(HPLC)(T)

  • 35543-24-9

  • 5g

  • 930.00CNY

  • Detail
  • Sigma-Aldrich

  • (Y0001529)  Buflomedil for peak identification  European Pharmacopoeia (EP) Reference Standard

  • 35543-24-9

  • Y0001529

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (B1157400)  Buflomedilhydrochloride  European Pharmacopoeia (EP) Reference Standard

  • 35543-24-9

  • B1157400

  • 1,880.19CNY

  • Detail
  • Sigma-Aldrich

  • (B5899)  Buflomedilhydrochloride  analytical standard

  • 35543-24-9

  • B5899-1G

  • 297.18CNY

  • Detail

35543-24-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride

1.2 Other means of identification

Product number -
Other names 4-(1-Pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone,Buflomedil hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35543-24-9 SDS

35543-24-9Synthetic route

1,2,3-trimethoxybenzene
621-23-8

1,2,3-trimethoxybenzene

4-(pyrrolidin-1-yl)butanoyl chloride
713069-87-5

4-(pyrrolidin-1-yl)butanoyl chloride

Buflomedil hydrochloride
35543-24-9

Buflomedil hydrochloride

Conditions
ConditionsYield
Stage #1: 1,2,3-trimethoxybenzene; 4-(pyrrolidin-1-yl)butanoyl chloride With zinc(II) chloride In dichloromethane at 0 - 5℃; for 2h; Reflux;
Stage #2: With hydrogenchloride In ethanol at 60 - 70℃; for 1h;
60.2 g

35543-24-9Downstream Products

35543-24-9Relevant articles and documents

Preparation method of buflomedil hydrochloride

-

Paragraph 0006, (2018/04/02)

The invention relates to the field of medicine production, in particular to a preparation method of buflomedil hydrochloride. The preparation method comprises the steps as follows: synthesis of 1-pyrrolidyl methyl butyrate: 68.3 g of methyl 4-chlorobutyrate, 82.8 g of anhydrous potassium carbonate, 0.2 g of potassium iodide, 39.1 g of pyrrolidine and 500 mL of acetone are put in a dry reaction bottle and heated for a reflux reaction for 3 h, a reaction solution is cooled to the room temperature, potassium carbonate is filtered out, filtrate is dried under reduced pressure, 500 mL of dichloromethane is added and dissolved, an organic phase is washed with a saturated ammonium chloride aqueous solution until the pH is 7-8, the organic phase is dried with anhydrous magnesium sulfate and then concentrated for removal of dichloromethane, a concentrate is obtained and subjected to distillation under reduced pressure, a fraction at 107-109 DEG C is collected, and 80.1 g of 1-pyrrolidyl methylbutyrate is obtained. The process is simple, the reaction is safe, the synthesis route is short, raw materials are easy to obtain, the condition is mild, and the cost is lower.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 35543-24-9