cas 35550-94-8, 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL | Articles data ｜lookchem

Welcome to LookChem.com Sign In|Join Free

Article Database

Home > CAS Article list >
35550-94-8

Articles about 35550-94-8Total 1 be found

Article title
Article abstract
Author
Journal number and time
Download

Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis
Meropenem, a broad-spectrum parenteral β-lactam antibiotic, in combination with clavulanate has recently shown efficacy in patients with extensively drug-resistant tuberculosis. As a result of meropenem's short half-life and lack of oral bioavailability, the development of an oral therapy is warranted for TB treatment in underserved countries where chronic parenteral therapy is impractical. To improve the oral absorption of meropenem, several alkyloxycarbonyloxyalkyl ester prodrugs with increased lipophilicity were synthesized and their stability in physiological aqueous solutions and guinea pig as well as human plasma was evaluated. The stability of prodrugs in aqueous solution at pH 6.0 and 7.4 was significantly dependent on the ester promoiety with the major degradation product identified as the parent compound meropenem. However, in simulated gastrointestinal fluid (pH 1.2) the major degradation product identified was ring-opened meropenem with the promoiety still intact, suggesting the gastrointestinal environment may reduce the absorption of meropenem prodrugs in vivo unless administered as an enteric-coated formulation. Additionally, the stability of the most aqueous stable prodrugs in guinea pig or human plasma was short, implying a rapid release of parent meropenem.
Teitelbaum, Aaron M.,Meissner, Anja,Harding, Ryan A.,Wong, Christopher A.,Aldrich, Courtney C.,Remmel, Rory P.
p. 5605 - 5617
(2013/09/02)

More Articles about upstream products of 35550-94-8

More Articles about downstream products of 35550-94-8

Chemical Properties

Melting Point: 101 °C
Boiling Point: 294.2 °C at 760 mmHg
Flash Point:108.9 °C
Density: 1.074 g/cm³
Storage Temp.:2-8°C
Vapor Pressure: 0.000749mmHg at 25°C
Refractive Index: 1.565
PKA: 14.44±0.20(Predicted)
PSA: 20.23000
LogP: 2.44640

Show more

Global suppliers and manufacturers of 35550-94-8total 8 suppliers on LookChem

Company Name
Business Type
Min Order
FOB Price
Main Products
Contact

Dayang Chem (Hangzhou) Co.,Ltd.
Business Type:Lab/Research institutions
Min Order:1 Kilogram
FOB Price:USD $ 3.0-3.0 / Kilogram
Main Products:994
Country:

Shandong Mopai Biotechnology Co., LTD
Business Type:Lab/Research institutions
Min Order:1 Gram
FOB Price:No Data
Main Products:60
Country:

Antimex Chemical Limied
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:163
Country:

Chemlyte Solutions
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:198
Country:

ZHEJIANG JIUZHOU CHEM CO.,LTD
Business Type:Trading Company
Min Order:No Data
FOB Price:No Data
Main Products:27
Country:

Amadis Chemical Co., Ltd.
Business Type:Lab/Research institutions
Min Order:10 Milligram
FOB Price:No Data
Main Products:1
Country:

Chemical Technology Co.,LTD
Business Type:Other
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Shanghai Coupling Pharmaceutical R&D Co., Ltd.
Business Type:Lab/Research institutions
Min Order:No Data
FOB Price:No Data
Main Products:1
Country:

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 35550-94-8

About us - Payment - Contact us - Links - Help Center - Disclaimer
SiteMap | Manufacturers | VIP Product | Suppliers | CAS | New CAS | Cas Database | Article Data | Chemical Catalog | Product Name

©2008 LookChem.com,License:ICP NO.:Zhejiang16009103 complaints:service@lookchem.com
[Hangzhou]86-571-87562588,87562561,87562573 Our Legal adviser: Lawyer