35550-94-8 Usage
Uses
Used in Organic Synthesis:
6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL is used as a building block for the synthesis of various complex organic molecules due to its unique bicyclic structure and reactivity, enabling the development of new compounds with potential applications in pharmaceuticals, materials science, and other industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL is used as a precursor to various therapeutic compounds, leveraging its ability to be further functionalized to produce derivatives with potential medicinal properties.
Used in Material Science:
6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL is utilized as a starting material for the development of new materials with specific properties, such as improved stability or reactivity, by incorporating its unique structure into the material's composition.
Used in Coordination Chemistry:
As a ligand, 6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL is employed in coordination chemistry to form complexes with metal ions, which can exhibit novel properties or reactivities, contributing to the advancement of inorganic and organometallic chemistry.
Used in Research and Development:
6,7,8,9-TETRAHYDRO-5H-BENZO[7]ANNULEN-5-OL is used as a research compound to explore its chemical properties, reactivity, and potential applications in various fields, including the synthesis of new molecules and the development of innovative processes.
Check Digit Verification of cas no
The CAS Registry Mumber 35550-94-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,5,5 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 35550-94:
(7*3)+(6*5)+(5*5)+(4*5)+(3*0)+(2*9)+(1*4)=118
118 % 10 = 8
So 35550-94-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H14O/c12-11-8-4-2-6-9-5-1-3-7-10(9)11/h1,3,5,7,11-12H,2,4,6,8H2
35550-94-8Relevant academic research and scientific papers
Synthesis, pH-dependent, and plasma stability of meropenem prodrugs for potential use against drug-resistant tuberculosis
Teitelbaum, Aaron M.,Meissner, Anja,Harding, Ryan A.,Wong, Christopher A.,Aldrich, Courtney C.,Remmel, Rory P.
, p. 5605 - 5617 (2013/09/02)
Meropenem, a broad-spectrum parenteral β-lactam antibiotic, in combination with clavulanate has recently shown efficacy in patients with extensively drug-resistant tuberculosis. As a result of meropenem's short half-life and lack of oral bioavailability, the development of an oral therapy is warranted for TB treatment in underserved countries where chronic parenteral therapy is impractical. To improve the oral absorption of meropenem, several alkyloxycarbonyloxyalkyl ester prodrugs with increased lipophilicity were synthesized and their stability in physiological aqueous solutions and guinea pig as well as human plasma was evaluated. The stability of prodrugs in aqueous solution at pH 6.0 and 7.4 was significantly dependent on the ester promoiety with the major degradation product identified as the parent compound meropenem. However, in simulated gastrointestinal fluid (pH 1.2) the major degradation product identified was ring-opened meropenem with the promoiety still intact, suggesting the gastrointestinal environment may reduce the absorption of meropenem prodrugs in vivo unless administered as an enteric-coated formulation. Additionally, the stability of the most aqueous stable prodrugs in guinea pig or human plasma was short, implying a rapid release of parent meropenem.
