- Substituted Pyrrolidines and Methods of Use
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The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
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Paragraph 2072
(2018/04/20)
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- Substituted Pyrrolidines and Methods of Use
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The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
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Paragraph 1538
(2018/04/20)
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- Expedient synthesis of tetrahydroquinoline-3-spirohydantoin derivatives: Via the Lewis acid-catalyzed tert -amino effect reaction
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Magnesium triflate was found to effectively catalyze the tert-amino effect reaction (T-reaction) involving ethyl 3-(2-(dialkylamino)-phenyl)-2-nitroacrylates leading to tetrahydroquinoline nitroester derivatives. These compounds can be readily transformed
- Briones, John F.,Basarab, Gregory S.
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supporting information
p. 8541 - 8544
(2016/07/13)
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- Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents
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A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts. Taylor & Francis Group, LLC.
- Samadi, Abdelouahid,Silva, Daniel,Chioua, Mourad,Carreiras, Maria Do Carmo,Marco-Contelles, Jose
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experimental part
p. 2859 - 2869
(2011/09/12)
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