35567-32-9Relevant academic research and scientific papers
Substituted Pyrrolidines and Methods of Use
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Paragraph 2072, (2018/04/20)
The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Substituted Pyrrolidines and Methods of Use
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Paragraph 1538, (2018/04/20)
The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.
Expedient synthesis of tetrahydroquinoline-3-spirohydantoin derivatives: Via the Lewis acid-catalyzed tert -amino effect reaction
Briones, John F.,Basarab, Gregory S.
supporting information, p. 8541 - 8544 (2016/07/13)
Magnesium triflate was found to effectively catalyze the tert-amino effect reaction (T-reaction) involving ethyl 3-(2-(dialkylamino)-phenyl)-2-nitroacrylates leading to tetrahydroquinoline nitroester derivatives. These compounds can be readily transformed
Microwave irradiation-assisted amination of 2-chloropyridine derivatives with amide solvents
Samadi, Abdelouahid,Silva, Daniel,Chioua, Mourad,Carreiras, Maria Do Carmo,Marco-Contelles, Jose
experimental part, p. 2859 - 2869 (2011/09/12)
A simple, quick, and high-yielding microwave-assisted synthesis of 2-(N,Ndimethyl) amine- and 2-aminopyridine derivatives is reported here for the first time in the reaction of 2-chloro substituted pyridines with amide solvents such as dimethylformamide or formamide, without transition-metal catalysts. Taylor & Francis Group, LLC.
