355808-90-1Relevant articles and documents
Translation of microwave methodology to continuous flow for the efficient synthesis of diaryl ethers via a base-mediated SNAr reaction
Wiles, Charlotte,Watts, Paul
experimental part, p. 1360 - 1371 (2011/12/15)
Whilst microwave heating has been widely demonstrated as a synthetically useful tool for rapid reaction screening, a microwaveabsorbing solvent is often required in order to achieve efficient reactant heating. In comparison, microreactors can be readily h
The application of stop-flow microwave technology to scaling-out S NAr reactions using a soluble organic base
Marafie, Jameel A.,Moseley, Jonathan D.
experimental part, p. 2219 - 2227 (2010/07/04)
A model SNAr reaction which gives a range of substituted diaryl ethers has been re-developed to function with the soluble organic base DBU in the place of insoluble potassium carbonate. Manufacture of these diaryl ethers has then been achieved by scaling-out in an automated stop-flow microwave reactor to give productivities of >0.5 kg per day. Analogous reaction partners have also been scaled up in this reactor to extend the scope of the study. Brief comparison in a scale-up batch microwave reactor is also made. Lastly, continuous 24 h processing is reported in this small microwave stop-flow reactor, which requires no manual intervention once started.
A commercial continuous flow microwave reactor evaluated for scale-up
Bergamelli, Fabio,Iannelli, Mauro,Marafie, Jameel A.,Moseley, Jonathan D.
experimental part, p. 926 - 930 (2011/03/19)
Six pharmaceutically relevant reactions covering a range of physical parameters have been investigated in a commercially available microwave flow reactor. The reaction conditions were scaled-up from tube or large batch scale microwave conditions, largely
