99-54-7Relevant articles and documents
Doyle et al.
, p. 3494 (1977)
Ipso Nitration of Aryl Boronic Acids Using Fuming Nitric Acid
Baucom, Kyle D.,Brown, Derek B.,Caille, Seb,Murray, James I.,Quasdorf, Kyle,Silva Elipe, Maria V.
supporting information, (2021/06/30)
The ipso nitration of aryl boronic acid derivatives has been developed using fuming nitric acid as the nitrating agent. This facile procedure provides efficient and chemoselective access to a variety of aromatic nitro compounds. While several activating agents and nitro sources have been reported in the literature for this synthetically useful transformation, this report demonstrates that these processes likely generate a common active reagent, anhydrous HNO3. Kinetic and mechanistic studies have revealed that the reaction order in HNO3 is >2 and indicate that the ?NO2 radical is the active species.
Preparation method of 1,2-dichloro-4-nitrobenzene
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Paragraph 0007, (2020/04/17)
The invention discloses a preparation method of 1,2-dichloro-4-nitrobenzene. The preparation method comprises the following steps: adding p-nitrochlorobenzene into a sulfuric acid solution with a massfraction of 65%, carrying out stirring for dissolving of the p-nitrochlorobenzene, conducting heating to 55 DEG C, then adding potassium chlorate, carrying out a stirring and heat-preserved reactionfor 8 h, performing cooling with ice water after the reaction is completed, extracting a reaction solution with a carbon tetrachloride solution, conducting liquid separation, subjecting an organic phase to washing by an aqueous sulphurous acid solution with a mass fraction of 6%, an aqueous sodium hydroxide solution with a mass fraction of 12% and water in sequence, carrying out drying, evaporating an organic solution to dryness, and performing recrystallizing to obtain a yellow acicular crystal, namely the product 1,2-dichloro-4-nitrobenzene. The preparation method is simple in synthesis process, improved in product yield and mild in reaction conditions, and has practical application and promotion values.