356-42-3

Basic information

• Product Name: Perfluoropropionic anhydride
• Synonyms: 1,1,2,2,2-Pentafluoropropanoic anhydride;2,2,3,3,3-Pentafluoropropionic acid anhydride;Perfluoropropionic acid anhydride;Propanoic acid, pentafluoro-, anhydride;Propionic acid, pentafluoro-, anhydride;PFAA;PERFLUOROPROPIONIC ANHYDRIDE;PFPA
• CAS NO: 356-42-3
• Molecular Formula: C₆F₁₀O₃
• Molecular Weight: 310.05
• EINECS: 206-604-2
• Product Categories: Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Enzymes;-Glucuronidase;-Glucuronidase Drug Analysis Bundle;Inhibitors;Organic Building Blocks;Acylation Reagent;Small molecule;Acylation (GC Derivatizing Reagents);Analytical Chemistry;GC Derivatizing Reagents;organofluorine compounds;Analytical and Industrial Enzymes;PFPA - Pentafluoropropionic anhydride;βand Substrates;Biochemicals and Reagents;Building Blocks
• Mol File: 356-42-3.mol

Chemical Properties

• Melting Point: -43
• Boiling Point: 69-70 °C735 mm Hg(lit.)
• Flash Point: None
• Appearance: Clear colorless/Liquid
• Density: 1.571 g/mL at 25 °C(lit.)
• Vapor Pressure: 129mmHg at 25°C
• Refractive Index: 1.3
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility: Reacts with water.
• Sensitive: Moisture Sensitive
• BRN: 1806446
• CAS DataBase Reference: Perfluoropropionic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Perfluoropropionic anhydride(356-42-3)
• EPA Substance Registry System: Perfluoropropionic anhydride(356-42-3)

Safety Data

• Hazard Codes: C
• Statements: 34-14
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 356-42-3(Hazardous Substances Data)

Usage

Uses

1. Used in Gas Chromatography-Mass Spectrometry (GC-MS) Analysis:
Perfluoropropionic anhydride is used as a derivatizing agent for the analysis of stereoisomer content of synthetic peptides. It is also utilized in a GC-MS detection method for synephrine in dietary supplements.
2. Used in Pharmaceutical and Analytical Chemistry:
Perfluoropropionic anhydride acts as a derivatizing agent for amines and alcohols. It is used in the preparation of halogenated derivatives of phenolic acids, which are essential for determining some biologically important acids in cerebrospinal fluid.
3. Used in Neurochemistry Research:
In the field of neurochemistry, Perfluoropropionic anhydride serves as a derivatization reagent for the detection of endogenous amines, such as 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline, from non-treated rat brain by GC-multiple ion detection.
4. Used in Simultaneous Determination of Dopamine Metabolites:
Perfluoropropionic anhydride is employed in the simultaneous determination of the major metabolites of dopamine in rat striatum by gas-liquid chromatography, which is crucial for understanding the role of dopamine in various neurological processes and disorders.

InChI:InChI=1/C6F10O3/c7-3(8,5(11,12)13)1(17)19-2(18)4(9,10)6(14,15)16

Upstream product

• 422-59-3 2,2,3,3,3-pentafluoropropionyl chloride 
• 59239-87-1 bis(trifluoromethyl)phosphinous pentafluoropropionic anhydride 
• 422-64-0 pentafluoropropionic acid 

Downstream Products

• 57830-49-6 2-(trifluoromethylthio)pyridine 
• 107146-03-2 2-pyridyl pentafluoroethyl sulfide 
• 107146-04-3 2-(perfluoro-n-buthylthio)-pyridine 
• 107146-05-4 2-(perfluoroheptylthio)-pyridine 
• 77862-54-5 2,2,3,3,3-Pentafluoro-propionic acid 2-[methyl-(2,2,3,3,3-pentafluoro-propionyl)-amino]-1-[4-(2,2,3,3,3-pentafluoro-propionyloxy)-phenyl]-ethyl ester 
• 77774-26-6 2,2,3,3,3-Pentafluoro-propionic acid 2-[2-(2,2,3,3,3-pentafluoro-propionylamino)-ethyl]-phenyl ester 
• 378-72-3 1,1,1,2,2-pentafluoropentan-3-one 
• 426-65-3 ethyl Pentafluoropropionate 
• 1071001-01-8 1,1,1,2,2-pentafluoro-9-phenylnonan-3-one 
• 1071000-99-1 1,1,1,2,2-pentafluoro-8-phenyl-octan-3-one 
• 1071001-25-6 1,1,1,2,2-pentafluoro-5-(4-hexyloxyphenyl)pentan-3-one 
• 1141508-51-1 1-cyclohexyl-2-oxo-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-imidazo[2,1-a]isoquinolin-4-ium-3-ide 
• 55256-13-8 C₂₀H₇F₂₀NO₇ 
• 56728-12-2 3-Methoxy-4-hydroxyphenylethylenglykol-tris-pentafluorpropionat 

Relevant articles and documents

PROCESS FOR PRODUCING PERFLUORO ORGANIC PEROXIDE

To provide a process for safely producing a perfluoroacyl peroxide with good productivity. By supplying a perfluoroacyl halide-containing organic solvent solution, an aqueous solution of hydrogen peroxide or a metal peroxide, and an aqueous basic alkali metal compound solution to a tubular reactor to allow them to react with one another, in a flow rate ratio of, as represented by molar ratio of the compounds in the solutions, from 1.00 to 1.35 of the basic alkali metal compound and from 0.60 to 40 of hydrogen peroxide or the metal peroxide per 1 of the perfluoroacyl halide, the yield of a perfluoroacyl peroxide based on the material perfluoroacyl halide can be remarkably improved as compared with conventional technique.

Electrophilic Substitution in Indoles. Part 18. Cyclisation of N-Acetyltryptamines

Cyclisation of Nb-acetyltryptamines 8 with trifluoracetic anhydride, or pentafluoropropionic anhydride, affords spirocyclic indolines of types 14 and 15 in virtually quantitative yields.The mechanism of the reactions involves cyclisation by ipso-attack at the 3-position of the indole nucleus, to form spirocyclic 3H-indoles 12 and 13, which subsequently undergo addition of the anhydride to the 1,2-double bond of the 3H-indole.The generality of the latter reaction has been established by converting the 3H-indole-3-spirocyclopentane 16 and benzylideneaniline 18 into the anhydride adducts 17a and 19 respectively.The spirocyclic indoline adducts 14a, 14b, 15a, 15b and 17a are rapidly hydrolysed by dilute aqueous ammonia to the hydroxy spirocyclic indolines 20a, 20b, 21a, 21b and 17b respectively.