- Glycine receptor antagonist pharmacophore
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Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer''s disease, amyotrophic lateral sclerosis, Huntington''s disease and Down''s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a compound which has high binding to the glycine receptor.
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- Singel-Oxygen Photolysis of Dihaloketones. A Facile and Efficient Approach to Vicinal Triketones and Their Monohydrates
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The preparation of vic-triketones and/or their monohydrates by sensitized photooxidation (singlet oxygen) of gem-dihaloketones and/or vic-dihaloketones is described; some reaction mechanisms are discussed.
- Mahran, M. Refat,Abdou, Wafaa M.,Sidky, Mahmoud M.,Wamhoff, Heinrich
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p. 506 - 508
(2007/10/02)
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