356534-04-8

Basic information

• Product Name: (4-fluoro-2-methylphenyl)hydrazine
• Synonyms: (4-Fluoro-2-methylphenyl)hydrazine;(4-fluoro-2-Methylphenyl)hydrazine hydrochloride
• CAS NO: 356534-04-8
• Molecular Formula: C₇H₉FN₂
• Molecular Weight: 140.16
• Mol File: 356534-04-8.mol

Chemical Properties

• Boiling Point: 215.4°C at 760 mmHg
• Flash Point: 84.1°C
• Appearance: /
• Density: 1.202
• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.594
• PKA: 5.36±0.27(Predicted)
• CAS DataBase Reference: (4-fluoro-2-methylphenyl)hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluoro-2-methylphenyl)hydrazine(356534-04-8)
• EPA Substance Registry System: (4-fluoro-2-methylphenyl)hydrazine(356534-04-8)

Safety Data

• Hazardous Substances Data: 356534-04-8(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
(4-Fluoro-2-methylphenyl)hydrazine is used as a reagent in chemical synthesis for its high reactivity, allowing for the formation of a variety of complex organic compounds. Its unique substitution pattern with a fluorine and a methyl group on the phenyl ring provides specific reactivity and selectivity in reactions, making it suitable for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (4-Fluoro-2-methylphenyl)hydrazine is used as an intermediate in the synthesis of various drug molecules. Its presence in the molecular structure can influence the pharmacokinetic and pharmacodynamic properties of the final drug, such as solubility, stability, and biological activity. The specific substitution pattern of the compound can also contribute to the drug's selectivity for certain biological targets, potentially leading to more effective and safer medications.
Used in Agrochemical Industry:
(4-Fluoro-2-methylphenyl)hydrazine is also utilized in the agrochemical industry as a precursor for the development of new pesticides and herbicides. Its reactivity and structural features can be exploited to create molecules with improved efficacy, selectivity, and environmental compatibility. (4-Fluoro-2-methylphenyl)hydrazine's ability to form a range of derivatives can lead to the discovery of novel agrochemicals with enhanced performance and reduced impact on non-target organisms.
Used in Research and Development:
In research and development settings, (4-Fluoro-2-methylphenyl)hydrazine serves as a valuable tool for exploring new chemical reactions and mechanisms. Its high reactivity and unique structural features make it an ideal candidate for studying various organic transformations, such as cross-coupling, oxidation, and reduction reactions. Understanding these reactions can provide insights into the design of new synthetic routes and the development of more efficient and sustainable chemical processes.

InChI:InChI=1/C7H9FN2/c1-5-4-6(8)2-3-7(5)10-9/h2-4,10H,9H2,1H3

Upstream product

• 452-71-1 4-fluor-2-methylaniline 
• 452-63-1 2-Bromo-5-fluorotoluene 

Relevant articles and documents

Cross-Coupling between Hydrazine and Aryl Halides with Hydroxide Base at Low Loadings of Palladium by Rate-Determining Deprotonation of Bound Hydrazine

Reported here is the Pd-catalyzed C–N coupling of hydrazine with (hetero)aryl chlorides and bromides to form aryl hydrazines with catalyst loadings as low as 100 ppm of Pd and KOH as base. Mechanistic studies revealed two catalyst resting states: an arylpalladium(II) hydroxide and arylpalladium(II) chloride. These compounds are present in two interconnected catalytic cycles and react with hydrazine and base or hydrazine alone to give the product. The selectivity of the hydroxide complex with hydrazine to form aryl over diaryl hydrazine was lower than that of the chloride complex, as well as the catalytic reaction. In contrast, the selectivity of the chloride complex closely matched that of the catalytic reaction, indicating that the aryl hydrazine is derived from this complex. Kinetic studies showed that the coupling process occurs by rate-limiting deprotonation of a hydrazine-bound arylpalladium(II) chloride complex to give an arylpalladium(II) hydrazido complex.

1, 5-DIHYDRO-PYRAZOLO (3, 4-D) PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TEATMENT OF CNS DISORDERS

The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterised by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X in

FUSED HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention relates to wherein each symbol is as defined in the specification. The compound has a superior mineral corticoidreceptorantagonistic action and is useful as an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like, a compound having a fused heterocycle, or a prodrug thereof, or a salt thereof; and an agent for the prophylaxis or treatment of hypertension, cardiac failure and the like.

Design and synthesis of new orally active inhibitors of human neutrophil elastase

To identify new orally active inhibitors, further modification of 1 (ONO-6818) was performed. Peptidic derivatives 4b, 4c and 4n showed more potent inhibitory activity than nonpeptidic derivatives 3a-c. As a result, a series of peptidic inhibitors, 4a-s a