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452-71-1

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452-71-1 Usage

Chemical Properties

colorlesstolightyellowliqui

Uses

4-Fluoro-2-methylaniline was used in the synthesis of 4-fluoro-N-[(E)-{7-methoxy-2-[4-(methylsulfanyl)phenyl]-1-benzofuran-5-yl}methylidene]-2-methylaniline.

Check Digit Verification of cas no

The CAS Registry Mumber 452-71-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 2 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 452-71:
(5*4)+(4*5)+(3*2)+(2*7)+(1*1)=61
61 % 10 = 1
So 452-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3

452-71-1 Well-known Company Product Price

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  • Alfa Aesar

  • (A11609)  4-Fluoro-2-methylaniline, 97%   

  • 452-71-1

  • 5g

  • 174.0CNY

  • Detail
  • Alfa Aesar

  • (A11609)  4-Fluoro-2-methylaniline, 97%   

  • 452-71-1

  • 25g

  • 750.0CNY

  • Detail

452-71-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluoro-2-methylaniline

1.2 Other means of identification

Product number -
Other names 4-F-2-MePhNH2

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:452-71-1 SDS

452-71-1Relevant articles and documents

4 - Fluorine substituted aryl amine compound and synthesis method thereof

-

Paragraph 0054-0056, (2021/09/22)

The invention discloses a synthesis method of 4 -fluorine substituted aryl amine compound, which comprises the following steps: 1) taking acyl-protected phenylhydroxylamine as a substrate, and generating 4 -fluorine substituted aniline compound under basic conditions by taking sulfonyl fluoride as a fluorine source in a polar solvent. 2) The deprotection is carried out under dilute acid conditions or Pd by catalytic hydrogenation to give the 4 - fluorine-substituted aryl amine compound. 4 - Fluorine substituted aniline compounds which are synthesized by the invention greatly increase the lipophilic property due to the introduction of fluorine atoms, and can be widely applied to preparation of fluorine-containing drugs and pesticide and dye intermediates. , The adopted raw materials are industrial products, are cheap and easily available, and are commercially available. 4 - Fluoroaryl aniline prepared by the method is high in yield, and the product with the purity 90% can be obtained in a yield of more than ≥ 99%. The method is simple to operate and low in cost, is very suitable for industrialization, and can be widely popularized and used.

Microwave-assisted protection of primary amines as 2,5-dimethylpyrroles and their orthogonal deprotection

Walia, Amit,Kang, Soosung,Silverman, Richard B

, p. 10931 - 10937 (2013/11/19)

Primary amines can be readily doubly protected as N-substituted 2,5-dimethylpyrroles. Although this protecting group is stable toward strong bases and nucleophiles, long reaction times are required for both the protection and deprotection steps, generally resulting in low deprotection yields. By employing microwave irradiation, protection and deprotection reaction times are dramatically reduced. Furthermore, deprotection with dilute hydrochloric acid in ethanol increases reaction yields. Diverse deprotection conditions have been developed in conjunction with microwave irradiation, so that protection as an N-substituted 2,5-dimethylpyrrole can be orthogonal to other standard amine protecting groups, such as tert-butyloxycarbonyl (Boc), carbobenzyloxy (Cbz), and 9-fluorenylmethyloxycarbonyl (Fmoc).

Molybdenum hexacarbonyl and DBU reduction of nitro compounds under microwave irradiation

Spencer, John,Anjum, Nazira,Patel, Hiren,Rathnam, Rajendra P.,Verma, Jason

, p. 2557 - 2558 (2008/02/13)

An ethanolic mixture of molybdenum hexacarbonyl and DBU mediates the reduction of nitroarenes to the corresponding anilines in excellent yields in 15-30 minutes under microwave irradiation. Georg Thieme Verlag Stuttgart.

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