- ACYL GUANIDINE SODIUM/PROTON EXCHANGE INHIBITORS AND METHOD
-
Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; and R1, R2, R3 and R4 are as defined herein, and where X is N, R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above acyl guanidines.
- -
-
Page/Page column 31-32
(2010/02/10)
-
- Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols
-
A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for β-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12-15 were found to retain the β-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.
- Condon,Cimarusti,Fox,Narayanan,Reid,Sundeen,Hauck
-
p. 913 - 922
(2007/10/06)
-
- Esters of tetrahydronaphthyloxy-aminopropanols
-
Compounds having the formula STR1 wherein R1 is lower alkyl; R3, R4, R5, R6, and R7 are the same or different and are hydrogen or lower alkyl; R8, R9, and R10 are the same or different and are hydrogen, lower alkyl, lower alkoxy or cycloalkyl; and R11 is acyl; are useful in the treatment of coronary diseases.
- -
-
-
- Tetrahydronaphthyloxy-aminopropanols and salts thereof
-
This invention relates to new tetrahydronaphthyloxy-aminopropanols and related compounds of the formula SPC1 And to salts of such compounds, which are useful in coronary diseases.
- -
-
-