3588-75-8Relevant articles and documents
A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase
Bassett, John W.,Cassidy, Pamela B.,Escobedo, Jorge O.,Laws, Madeleine,Mafireyi, Tendai J.,Strongin, Robert M.
supporting information, p. 15147 - 15151 (2020/07/02)
We report the first diselenide-based probe for the selective detection of thioredoxin reductase (TrxR), an enzyme commonly overexpressed in melanomas. The probe design involves conjugation of a seminaphthorhodafluor dye with a diselenide moiety. TrxR redu
Investigation of the hydrogen bond donating ability of 1,8-naphthalenediol by NMR spectroscopy and its use as a hydrogen bonding catalyst
Turkmen, Yunus Emre
, p. 1398 - 1407 (2018/10/23)
The hydrogen bond donating ability of 1,8-naphthalenediol was investigated via a series of 1H, 13C, and 31P NMR experiments. Complexation studies using triphenylphosphine oxide and cyclohexanone as hydrogen bond acceptors
MOLECULAR PROBES FOR DETECTION AND IMAGING OF PANCREATIC CANCER
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Page/Page column 21, (2017/12/29)
Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.
A concise approach to the dalesconol skeleton
Fan, Yukai,Feng, Pengju,Liu, Mao,Pan, Hongjie,Shi, Yian
supporting information; experimental part, p. 4494 - 4497 (2011/10/11)
A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization-cyclization and a following one-pot consecutive operation.
SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B
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Page/Page column 7; 65-66, (2011/09/19)
This invention relates to compounds having the structure: wherein bonds α, β, γ, δ, ω, η, χ, ε, κ, and μ are each present or absent, and R1-R18 are various substituents described herein.
Total syntheses of dalesconol A and B
Snyder, Scott A.,Sherwood, Trevor C.,Ross, Audrey G.
supporting information; experimental part, p. 5146 - 5150 (2010/11/04)
(Chemical equation Presented) (Chemical equation Presented) A polycyclic collapse: Use of a carefully designed acyclic intermediate participated in a cascade reaction that formed the entire core of the polyketide-derived dalesconols in a single flask (see scheme). A number of additional and carefully controlled synthetic operations completed an expeditious synthesis of both of these highly bioactive natural products as well as structural congenors.
Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester
Aaseng, Jon Erik,Gautun, Odd R.
experimental part, p. 8982 - 8991 (2011/01/04)
This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.
Transformation of 5-methoxy-1-tetralone into 8-methoxy-1-tetralone
Banerjee, Ajoy K.,Bedoya, Liadis,Adherian, Maria E.,Vera, William J.,Cabrera, Elvia V.,Kariney, Elidig R.
experimental part, p. 522 - 524 (2010/12/25)
The transformation of 1-hydroxy-5-methoxtetralin into 4-hydroxy-8-methoxy- 1-tetralone was accomplished in three steps (benzoylation, oxidation and alkaline hydrolysis). Treatment of the corresponding ketotosylate with sodium iodide and zinc dust in dimet
Isomerization of 7-oxabenzonorbornadienes into naphthols catalyzed by [RuCl2(CO)3]2
Ballantine, Melissa,Menard, Michelle L.,Tam, William
supporting information; experimental part, p. 7570 - 7573 (2009/12/28)
(Chemical Equation Presented) Ruthenium-catalyzed isomerization of 7-oxanorbornadienes into naphthols was investigated. Among the various ruthenium catalysts tested, [RuCl2(CO)3]2 gave the highest yields in the isomerizati