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8-Methoxynaphthalene-1-ol is an organic compound with the chemical formula C11H10O2. It is a derivative of naphthalene, featuring a hydroxyl group (-OH) at the 1-position and a methoxy group (-OCH3) at the 8-position. This white crystalline solid is soluble in organic solvents and has a distinct aromatic odor. It is primarily used as a synthetic intermediate in the production of various pharmaceuticals, agrochemicals, and fragrances. The compound is synthesized through various methods, including the methylation of 8-naphthol or the demethylation of 8-methoxy-1-methylnaphthalene. Due to its potential applications and chemical properties, 8-methoxynaphthalene-1-ol is an important compound in the field of organic chemistry.

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  • 3588-75-8 Structure
  • Basic information

    1. Product Name: 8-Methoxynaphthalene-1-ol
    2. Synonyms: 8-Methoxynaphthalene-1-ol;8-Methoxy-1-naphthol;8-Methoxynaphthalen-1-ol;1-Methoxy-8-naphthol
    3. CAS NO:3588-75-8
    4. Molecular Formula: C11H10O2
    5. Molecular Weight: 174.1959
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 3588-75-8.mol
  • Chemical Properties

    1. Melting Point: >280℃
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 8-Methoxynaphthalene-1-ol(CAS DataBase Reference)
    10. NIST Chemistry Reference: 8-Methoxynaphthalene-1-ol(3588-75-8)
    11. EPA Substance Registry System: 8-Methoxynaphthalene-1-ol(3588-75-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3588-75-8(Hazardous Substances Data)

3588-75-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3588-75-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,5,8 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3588-75:
(6*3)+(5*5)+(4*8)+(3*8)+(2*7)+(1*5)=118
118 % 10 = 8
So 3588-75-8 is a valid CAS Registry Number.

3588-75-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-hydroxy-8-methoxynaphthalene

1.2 Other means of identification

Product number -
Other names 8-Methoxynaphthalene-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3588-75-8 SDS

3588-75-8Relevant articles and documents

A Diselenide Turn-On Fluorescent Probe for the Detection of Thioredoxin Reductase

Bassett, John W.,Cassidy, Pamela B.,Escobedo, Jorge O.,Laws, Madeleine,Mafireyi, Tendai J.,Strongin, Robert M.

supporting information, p. 15147 - 15151 (2020/07/02)

We report the first diselenide-based probe for the selective detection of thioredoxin reductase (TrxR), an enzyme commonly overexpressed in melanomas. The probe design involves conjugation of a seminaphthorhodafluor dye with a diselenide moiety. TrxR redu

Investigation of the hydrogen bond donating ability of 1,8-naphthalenediol by NMR spectroscopy and its use as a hydrogen bonding catalyst

Turkmen, Yunus Emre

, p. 1398 - 1407 (2018/10/23)

The hydrogen bond donating ability of 1,8-naphthalenediol was investigated via a series of 1H, 13C, and 31P NMR experiments. Complexation studies using triphenylphosphine oxide and cyclohexanone as hydrogen bond acceptors

MOLECULAR PROBES FOR DETECTION AND IMAGING OF PANCREATIC CANCER

-

Page/Page column 21, (2017/12/29)

Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.

A concise approach to the dalesconol skeleton

Fan, Yukai,Feng, Pengju,Liu, Mao,Pan, Hongjie,Shi, Yian

supporting information; experimental part, p. 4494 - 4497 (2011/10/11)

A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization-cyclization and a following one-pot consecutive operation.

SYNTHESIS OF THE POTENT IMMUNOSUPPRESSANT AGENTS DALESCONOL A AND B

-

Page/Page column 7; 65-66, (2011/09/19)

This invention relates to compounds having the structure: wherein bonds α, β, γ, δ, ω, η, χ, ε, κ, and μ are each present or absent, and R1-R18 are various substituents described herein.

Total syntheses of dalesconol A and B

Snyder, Scott A.,Sherwood, Trevor C.,Ross, Audrey G.

supporting information; experimental part, p. 5146 - 5150 (2010/11/04)

(Chemical equation Presented) (Chemical equation Presented) A polycyclic collapse: Use of a carefully designed acyclic intermediate participated in a cascade reaction that formed the entire core of the polyketide-derived dalesconols in a single flask (see scheme). A number of additional and carefully controlled synthetic operations completed an expeditious synthesis of both of these highly bioactive natural products as well as structural congenors.

Synthesis of substituted (S)-2-aminotetralins via ring-opening of aziridines prepared from l-aspartic acid β-tert-butyl ester

Aaseng, Jon Erik,Gautun, Odd R.

experimental part, p. 8982 - 8991 (2011/01/04)

This paper describes the total synthesis of the hydrochloride salts of (2S)-2-amino-7-methoxytetralin (21-HCl) and (2S)-2-amino-6-fluoro-7- methoxytetralin (ST1214), from a common enantiomerically pure aziridine 4b, which was available from l-aspartic acid β-tert-butyl ester. The synthesis of 21-HCl and ST1214 proceeded in nine steps and 5 and 6% overall yields, respectively. Key steps are the regioselective ring-opening of 4b with ArMgBr/CuBr·SMe2 and the intramolecular Friedel-Crafts cyclisation providing α-tetralone. Substituted naphthalenes were formed as side products in the latter reaction.

Transformation of 5-methoxy-1-tetralone into 8-methoxy-1-tetralone

Banerjee, Ajoy K.,Bedoya, Liadis,Adherian, Maria E.,Vera, William J.,Cabrera, Elvia V.,Kariney, Elidig R.

experimental part, p. 522 - 524 (2010/12/25)

The transformation of 1-hydroxy-5-methoxtetralin into 4-hydroxy-8-methoxy- 1-tetralone was accomplished in three steps (benzoylation, oxidation and alkaline hydrolysis). Treatment of the corresponding ketotosylate with sodium iodide and zinc dust in dimet

Isomerization of 7-oxabenzonorbornadienes into naphthols catalyzed by [RuCl2(CO)3]2

Ballantine, Melissa,Menard, Michelle L.,Tam, William

supporting information; experimental part, p. 7570 - 7573 (2009/12/28)

(Chemical Equation Presented) Ruthenium-catalyzed isomerization of 7-oxanorbornadienes into naphthols was investigated. Among the various ruthenium catalysts tested, [RuCl2(CO)3]2 gave the highest yields in the isomerizati

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