cas 35995-21-2, 3-Hydroxy-1-ethylazetidin...

Methods of treating cardiac arrhythmias and convulsions in warm-blooded animas and pharmaceutical compositions therefor are disclosed. The compounds useful in the methods of treatment and compositions are represented by the formula STR1 where n is 0 to 3 and R is H, C1 -C4 alkyl or arylalkyl and Ar is phenyl or substituted phenyl.

Cyclization of either the tetrahydropyranyl or trimethylsilyl ether of 1-(alkylamino)-3-chloro-2-propanols 1 followed by cleavage of the azetidinyl ether provides a general method for the preparation of 1-alkyl-3-azetidinols.Unhindered amines provide a more facile preparation of derivatives of 1, or its ethers, than do hindered amines, while hindered derivatives of 1 undergo more facile ring closure.

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35995-21-2

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Chemical Properties

Boiling Point: 140.5±33.0 °C(Predicted)

Density: 1.047±0.06 g/cm3(Predicted)

Storage Temp.:2-8°C

PKA: 14.36±0.20(Predicted)

PSA: 23.47000

LogP: 0.42270

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