361436-24-0

Basic information

• Product Name: 1H-Indol-5-ol,3-(1-methylethyl)-(9CI)
• Synonyms: 1H-Indol-5-ol,3-(1-methylethyl)-(9CI)
• CAS NO: 361436-24-0
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Product Categories: ISOPROPYL;CYCLOHEXANE
• Mol File: 361436-24-0.mol

Chemical Properties

• Boiling Point: 347.0±22.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• PKA: 10.14±0.40(Predicted)
• CAS DataBase Reference: 1H-Indol-5-ol,3-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indol-5-ol,3-(1-methylethyl)-(9CI)(361436-24-0)
• EPA Substance Registry System: 1H-Indol-5-ol,3-(1-methylethyl)-(9CI)(361436-24-0)

Safety Data

• Hazardous Substances Data: 361436-24-0(Hazardous Substances Data)

Usage

Structure

Bicyclic heterocyclic organic molecule derived from indole

Usage

Building block in organic synthesis and pharmaceutical research

Biological activities

Anti-inflammatory and anti-cancer properties

Potential applications

Development of new drugs and agrochemicals

Note

Specific roles and mechanisms of action still under investigation

Upstream product

• 361435-94-1 5-benzyloxy-3-isopropyl-1H-indole 
• 51145-58-5 [4-(benzyloxy)phenyl]hydrazine 
• 590-86-3 isovaleraldehyde 
• 3471-32-7 4-Methoxyphenylhydrazine 

Downstream Products

• 361435-65-6 5-(2,6-dimethyl-4-nitrophenoxy)-3-isopropyl-1H-indole 
• 439612-43-8 5-(2-chloro-6-methyl-4-nitrophenoxy)-3-isopropyl-1H-indole 
• 361435-57-6 5-(2,6-dibromo-4-nitro-phenoxy)-3-isopropyl-1H-indole 
• 361435-59-8 3-isopropyl-5-(4-nitro-2,6-divinyl-phenoxy)-1H-indole 
• 361435-62-3 3,5-dicyclopropyl-4-(3-isopropyl-1H-indol-5-yloxy)-phenylamine 
• 361435-61-2 5-(2,6-dicyclopropyl-4-nitro-phenoxy)-3-isopropyl-1H-indole 
• 439612-42-7 5-(2,6-dichloro-4-nitrophenoxy)-3-isopropyl-1H-indole 
• 439612-46-1 4-(3-Isopropyl-1H-indol-5-yloxy)-3,5-bis-trifluoromethyl-benzaldehyde 
• 439612-12-1 ethyl N-{4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}glycinate 
• 439612-11-0 3-({4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}amino)-3-oxopropanoic acid 
• 439612-10-9 methyl 3-({4-[(3-isopropyl-1H-indol-5-yl)oxy]-3,5-dimethylphenyl}amino)-3-oxopropanoate 
• 439612-13-2 methyl 3-({3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methylphenyl}amino)-3-oxo-propanoate 
• 1026907-93-6 isopropyl 3-({3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methylphenyl}-amino)-3-oxo-propanoate 
• 1026303-34-3 2-Hydroxyethyl 3-({3-chloro-4-[(3-isopropyl-1H-indol-5-yl)oxy]-5-methylphenyl}-amino)-3-oxopropanoate 

Relevant articles and documents

THYROID HORMONE RECEPTOR AGONISTS

Provided herein are novel thyroid hormone receptor (TR) agonists, e. g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.

MODULATORS OF THR-β AND METHODS OF USE THEREOF

Disclosed herein are compounds of Formula (I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IlIa, lIIb, IlIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.

Novel heterocyclic thyromimetics

Novel heterocycle-fused thyromimetics are presented carrying indoles or indazoles instead of the phenolic group in T3. Potent agonists were identified in both series. SAR trends are examined and found to be mostly consistent with previously published thyromimetics. Moderate THRβ selectivity (approx. 10-fold) was observed in the indole series using isoform-selective transient THR transfection assays