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2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE, also known as AMG-232, is a synthetic acetamide compound with a molecular weight of 283.71 g/mol. It has potential antineoplastic activity and has been studied for its potential use in cancer treatment, specifically targeting the p53 pathway, which is often mutated in cancer cells.

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  • Acetamide,2-chloro-N-(6-methoxy-3-pyridinyl)-

    Cas No: 36145-27-4

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  • 36145-27-4 Structure
  • Basic information

    1. Product Name: 2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE
    2. Synonyms: N-(6-Methoxy-3-pyridyl)-a-chloroacetamide;2-Chloro-N-(6-methoxypyridin-3-yl)acetamide;
    3. CAS NO:36145-27-4
    4. Molecular Formula: C8H9ClN2O2
    5. Molecular Weight: 200.62
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 36145-27-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 371.1 °C at 760 mmHg
    3. Flash Point: 178.2 °C
    4. Appearance: /
    5. Density: 1.327 g/cm3
    6. Vapor Pressure: 1.06E-05mmHg at 25°C
    7. Refractive Index: 1.577
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE(36145-27-4)
    12. EPA Substance Registry System: 2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE(36145-27-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 36145-27-4(Hazardous Substances Data)

36145-27-4 Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE is used as an antineoplastic agent for its potential to inhibit the growth of cancer cells and induce apoptosis. It targets the p53 pathway, which is often mutated in cancer cells, and has shown promising results in preclinical studies.
Used in Cancer Research:
2-CHLORO-N-(6-METHOXYPYRIDIN-3-YL)ACETAMIDE is used as a research compound to further investigate its potential therapeutic applications in the treatment of various types of cancer. Further research and clinical trials are needed to fully assess its safety and efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 36145-27-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,1,4 and 5 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36145-27:
(7*3)+(6*6)+(5*1)+(4*4)+(3*5)+(2*2)+(1*7)=104
104 % 10 = 4
So 36145-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClN2O2/c1-13-8-3-2-6(5-10-8)11-7(12)4-9/h2-3,5H,4H2,1H3,(H,11,12)

36145-27-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-N-(6-methoxypyridin-3-yl)acetamide

1.2 Other means of identification

Product number -
Other names N-(2-Methoxy-5-pyridyl)-chloroacetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36145-27-4 SDS

36145-27-4Downstream Products

36145-27-4Relevant articles and documents

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

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Paragraph 0262, (2020/02/19)

Substituted -3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and Stimulator for Interferon Genes (STING) modulators as cancer immunotherapeutics

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Paragraph 0319; 0320, (2019/02/13)

Substituted-3H-imidazo[4,5-c]pyridine and 1H-pyrrolo[2,3-c]pyridine series of novel Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) and related compounds, which are useful as inhibitors of ENPP1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the ENPP1.

Fungicidal N-pyridyl haloamides

-

, (2008/06/13)

Novel fungicidal pyridyl cyclopropane carboxamides having the general structural formula STR1 wherein R is selected from the group consisting of C1 -C3 alkoxy, C1 -C3 haloalkoxy and halogen; and R1 is C1 -C6 haloalkyl; and fungicidally acceptable organic and inorganic salts thereof.

Acaricidal compositions of phosphoramidate esters

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, (2008/06/13)

This invention discloses new compounds of the formula STR1 WHEREIN R1 is selected from the group consisting of alkyl, alkenyl and STR2 WHEREIN A is selected from the group consisting of alkyl, alkenyl, alkoxy, alkylthio, halogen, nitro, dialkyl

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