- Iron triflate catalyzed reductive amination of aldehydes using sodium borohydride
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An efficient and convenient procedure for the reductive amination of aldehydes using NaBH4 in the presence of catalytic amount of Fe(OTf)3 is described.
- Uday Kumar,Sudhakar Reddy,Prabhakar Reddy,Bandichhor, Rakeshwar
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supporting information; experimental part
p. 4354 - 4356
(2012/10/08)
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- SYNTHESIS ROUTES TO 2(S),4(S),5(S),7(S)-2,7-DIALKYL-4-HYDROXY-5-AMINO-8-ARYL-OCTANOYL AMIDES
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The invention relates to a process for the preparation of compounds that are important building blocks in convergent synthesis routes to 2(S),4(S),5(S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides or pharmaceutically acceptable salts thereof, such as the compound Aliskiren, and to a process for the preparation of these octanoyl amides, comprising reacting said building block.
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Page/Page column 39
(2010/04/03)
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- Formal total synthesis of the potent renin inhibitor aliskiren: Application of a SmI2-promoted acyl-like radical coupling
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A formal total synthesis of the potent renin inhibitor aliskiren is disclosed exploiting an alternative coupling strategy recently developed by this laboratory for the preparation of the hydroxyethylene isostere-based class of protease inhibitors. The thi
- Lindsay, Karl B.,Skrydstrup, Troels
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p. 4766 - 4777
(2007/10/03)
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- Process for the preparation of aryloctanoyl amides
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Compounds of formula IwhereinR1is for example 3-methoxyprop-3-yloxy, R2is for example methoxy, R3and R4are in each case for example isopropyl, and R5is H2NC(O)-[C(CH3)2]-CH2-, are obtainable by reaction of compounds of formula IV(IV) with a metal organic derivative of 1-(3-R1-4-R2-phen-1-yl)-2-R3-3-halogen propanes to form a compound of formula VI,followed by removal of the pseudoephedrine protecting group and the OH group, reaction of the resulting lactone with an amine R5-NH2and removal of protecting group Z.
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