362485-20-9Relevant articles and documents
5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Ruebsam, Frank,Tran, Chinh V.,Li, Lian-Sheng,Kim, Sun Hee,Xiang, Alan X.,Zhou, Yuefen,Blazel, Julie K.,Sun, Zhongxiang,Dragovich, Peter S.,Zhao, Jingjing,McGuire, Helen M.,Murphy, Douglas E.,Tran, Martin T.,Stankovic, Nebojsa,Ellis, David A.,Gobbi, Alberto,Showalter, Richard E.,Webber, Stephen E.,Shah, Amit M.,Tsan, Mei,Patel, Rupal A.,LeBrun, Laurie A.,Hou, Huiying J.,Kamran, Ruhi,Sergeeva, Maria V.,Bartkowski, Darian M.,Nolan, Thomas G.,Norris, Daniel A.,Kirkovsky, Leo
scheme or table, p. 451 - 458 (2011/03/20)
5,6-Dihydro-1H-pyridin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Among these, compound 4ad displayed potent inhibitory activities in biochemical and replicon assays (IC50 (1b) 10 nM; ICsu