- The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase
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A series of compounds was rationally designed as inhibitors of dimer formation of the inducible isoform of nitric oxide synthase, and subsequent nitric oxide production. The conformation of two fragments obtained from a crystal structure was utilized to d
- Whitlow, Marc,Adler, Marc,Davey, David,Huang, Qinglan,Koovakkat, Sunil,Parkinson, John F.,Pham, Eric,Polokoff, Mark,Xu, Wei,Yuan, Shendong,Phillips, Gary
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- N-heterocyclic derivatives as NOS inhibitors
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N-Heterocyclic derivatives selected from the group consisting of the following formulae: where Z1, Z2, Z3, R1, R2, R3, R4, R5 and R6 are described herein, a
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