The Thioesterase of the Erythromycin-producing Polyketide Synthase: Mechanistic Studies in vitro to Investigate its Mode of Action and Substrate Specificity
In vitro studies of the mode of action of the thioesterase of the erythromycin-producing PKS have shown that it cleaves ester groups by forming acyl enzyme intermediates, and that it has a broad substrate specificity.
Aggarwal, Ranjana,Caffrey, Patrick,Leadlay, Peter F.,Smith, Cameron J.,Staunton, James