The Thioesterase of the Erythromycin-producing Polyketide Synthase: Mechanistic Studies in vitro to Investigate its Mode of Action and Substrate Specificity

DOI: 10.1039/c39950001519

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1519 - 1520 (1995)

Update date:2022-09-26

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Authors:

Aggarwal, Ranjana

Caffrey, Patrick

Leadlay, Peter F.

Smith, Cameron J.

Staunton, James

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Article abstract of DOI:10.1039/c39950001519

In vitro studies of the mode of action of the thioesterase of the erythromycin-producing PKS have shown that it cleaves ester groups by forming acyl enzyme intermediates, and that it has a broad substrate specificity.

Full text of DOI:10.1039/c39950001519

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