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N-(2,3,4-trifluorophenyl)acetamide is a chemical compound with the formula C8H6F3NO. It is an organic amide characterized by the presence of a carbonyl group attached to an amine group. N-(2,3,4-trifluorophenyl)acetaMide is known for its strong electron-withdrawing properties, which make it a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and materials for organic electronics.

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  • 365-29-7 Structure
  • Basic information

    1. Product Name: N-(2,3,4-trifluorophenyl)acetaMide
    2. Synonyms: N-(2,3,4-trifluorophenyl)acetaMide;2',3',4'-Trifluoroacetanilide
    3. CAS NO:365-29-7
    4. Molecular Formula: C8H6F3NO
    5. Molecular Weight: 189.1345496
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 365-29-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(2,3,4-trifluorophenyl)acetaMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(2,3,4-trifluorophenyl)acetaMide(365-29-7)
    11. EPA Substance Registry System: N-(2,3,4-trifluorophenyl)acetaMide(365-29-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 365-29-7(Hazardous Substances Data)

365-29-7 Usage

Uses

Used in Pharmaceutical Industry:
N-(2,3,4-trifluorophenyl)acetamide is used as a building block for the synthesis of various pharmaceuticals. Its strong electron-withdrawing properties contribute to the development of new drugs with improved efficacy and safety profiles.
Used in Agrochemical Industry:
In the agrochemical industry, N-(2,3,4-trifluorophenyl)acetamide serves as a key component in the synthesis of novel agrochemicals. Its unique properties enable the creation of more effective and environmentally friendly pesticides and herbicides.
Used in Organic Electronics:
N-(2,3,4-trifluorophenyl)acetamide is utilized as a building block in the development of new materials for organic electronics. Its electron-withdrawing properties make it suitable for applications in organic light-emitting diodes (OLEDs), organic solar cells, and other electronic devices, enhancing their performance and stability.
Used in Chemical Reactions:
Due to its strong electron-withdrawing properties, N-(2,3,4-trifluorophenyl)acetamide is employed in a wide range of chemical reactions. It can act as a catalyst or intermediate, facilitating the synthesis of various organic compounds and improving the overall efficiency of the reaction process.

Check Digit Verification of cas no

The CAS Registry Mumber 365-29-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 365-29:
(5*3)+(4*6)+(3*5)+(2*2)+(1*9)=67
67 % 10 = 7
So 365-29-7 is a valid CAS Registry Number.

365-29-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,3,4-trifluorophenyl)acetamide

1.2 Other means of identification

Product number -
Other names 2,3,4-trifluoroacetanilide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:365-29-7 SDS

365-29-7Relevant articles and documents

A PROCESS FOR THE PREPARATION OF 3,4,5-TRIFLUORONITROBENZENE

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Page 6; 8, (2008/06/13)

The present invention relates to a process for the preparation of 3,4,5-trifluoronitrobenzene of the formula (1). The process involved straightforward transformations and eventually culminated in consistent preparation of the title compound in good quantities.

Synthesis of novel fluorobenzofuroxans by oxidation of anilines and thermal cyclization of arylazides

Leyva, Socorro,Castanedo, Víctor,Leyva, Elisa

, p. 171 - 175 (2007/10/03)

The synthesis of several fluorobenzofuroxans by oxidation of fluoroanilines and thermal cyclization of fluoroarylazides is presented. The fluorobenzofuroxans prepared in this study presented tautomerism as evidenced by their NMR data. Benzofuroxans in general have biological activity and are synthetic intermediates for the preparation of several compounds with important pharmaceutical applications.

Glycine receptor antagonists and the use thereof

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, (2008/06/13)

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, inducing anesthesia and treating psychosis are disclosed by administering to an animal in need of such treatment a compound having high affinity for the glycine binding site, lacking PCP side effects and which crosses the blood brain barrier of the animal. Also disclosed are novel 1,4-dihydroquinoxaline-2,3-diones, and pharmaceutical compositions thereof. Also disclosed are highly soluble ammonium salts of 1,4-dihydroquinoxaline-2,3-diones.

Synthesis and structure-activity relationships of substituted 1,4- dihydroquinoxaline-2,3-diones: Antagonists of N-methyl-D-aspartate (NMDA) receptor glycine sites and non-NMDA glutamate receptors

Keana,Kher,Sui Xiong Cai,Dinsmore,Glenn,Guastella,Huang,Ilyin,Lu,Mouser,Woodward,Weber

, p. 4367 - 4379 (2007/10/02)

A series of mono-, di-, tri-, and tetrasubstituted 1,4- dihydroquinoxaline-2,3-diones (QXs) were synthesized and evaluated as antagonists at N-methyl-D-aspartate (NMDA)/glycine sites and α-amino-3- hydroxy-5-methylisoxazole-4-propionic acid-preferring non-NMDA receptors. Antagonist potencies were measured by electrical assays in Xenopus oocytes expressing rat whole brain poly(A)+ RNA. Trisubstituted QXs 17a (ACEA 1021), 17b (ACEA 1031), 24a, and 27, containing a nitro group in the 5 position and halogen in the 6 and 7 positions, displayed high potency (K(b) ~ 6-8 nM) at the glycine site, moderate potency at non-NMDA receptors (K(b) = 0.9-1.5 μM), and the highest (120-250-fold) selectivity in favor of glycine site antagonism over non-NMDA receptors. Tetrasubstituted QXs 17d,e were more than 100-fold weaker glycine site antagonists than the corresponding trisubstituted QXs with F being better tolerated than Cl as a substituent at the 8 position. Di- and monosubstituted QXs showed progressively weaker antagonism compared to trisubstituted analogues. For example, removal of the 5-nitro group of 17a results in a ~100-fold decrease in potency (10a,b,z), while removal of both halogens from 17a results in a ~3000-fold decrease in potency (10v). In terms of steady-state inhibition, most QX substitution patterns favor antagonism at NMDA/glycine sites over antagonism at non-NMDA receptors. Among the QXs tested, only 17i was slightly selective for non- NMDA receptors.

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