- TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF
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Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.
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Page/Page column 62
(2019/05/22)
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- Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones
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A sequential one-pot strategy for the diversified synthesis of phthalazines, phthalazinones and benzoxazinones was presented. This strategy proceeds through [Pd]-catalyzed acylation and nucleophilic cyclocondensation with dinucleophilic reagents. This process was based on direct coupling with simple bench-top aldehydes without the assistance of directing group and without activating the carbonyl group. The process is highly advantageous because it employs simple nitrogen-based nucleophiles, and non-toxic and readily accessible aldehydes as the carbonyl source. Most importantly, the strategy was applied to the one-pot synthesis of PDE-4 inhibitor.
- Suchand, Basuli,Satyanarayana, Gedu
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p. 2233 - 2246
(2018/06/04)
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- Palladium-Catalyzed Carbonylative Synthesis of 3-Methyleneisoindolin-1-ones from Ketimines with Hexacarbonylmolybdenum(0) as the Carbon Monoxide Source
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An interesting procedure for the palladium-catalyzed carbonylative synthesis of 3-methyleneisoindolin-1-ones from ketimines was established. By using Mo(CO)6 (0.3 equiv.) as the solid CO source and through C(sp2)?H bond activation, t
- Wang, Zechao,Zhu, Fengxiang,Li, Yahui,Wu, Xiao-Feng
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- Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source
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A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO) 8 as carbonyl source making it rea
- Suresh, A. Sivalingam,Baburajan, Poongavanam,Ahmed, Mansur
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p. 3482 - 3485
(2014/06/10)
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- Ultrasound-promoted regio and chemoselective synthesis of pyridazinones and phthalazinones catalyzed by ionic liquid [bmim]Br/AlCl3
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The first ultrasound-promoted multicomponent synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides and ArNHNH2 in the presence of an efficient recyclable catalyst, [bmim]Br/AlCl3, in high yield and short reaction time is reported.
- Zare, Leila,Mahmoodi, Nosrat Ollah,Yahyazadeh, Asieh,Nikpassand, Mohammad
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experimental part
p. 740 - 744
(2012/05/20)
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- An efficient one-pot synthesis of pyridazinones and phthalazinones using HY-zeolite
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Figure represented. The first one-pot synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides, and ArNHNH2 in the presence of efficient recyclable heterogeneous catalyst, HY-zeolite, in high yield and short reaction time is reported.
- Zare, Leila,Mahmoodi, Nosratollah,Yahyazadeh, Asieh,Mamaghani, Manouchehr,Tabatabaeian, Khalil
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experimental part
p. 864 - 867
(2011/09/16)
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- An efficient chemo- and regioselective three-component synthesis of pyridazinones and phthalazinones using activated KSF
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The first three-component and regioselective synthesis of pyridazinones and phthalazinones from arenes, anhydrides and ArNHNH2 in the presence of efficient recyclable heterogeneous catalyst, montmorillonite-KSF, in high yield and short reaction time is reported.
- Zare,Mahmoodi,Yahyazadeh,Mamaghani,Tabatabaeian
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experimental part
p. 538 - 541
(2011/02/21)
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- Hydrazine derivatives and o-benzoylbenzoic acid as a source of phthalazines with their antimicrobial activities
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Starting from 2-benzoylbenzoic acid (1) and prototype hydrazine itself or some of its simple congeners produce phthalazin-1(2H)-one derivatives 2a-d. Reactions of 2 with P2S5 or POCl3 gave their thione derivatives 3a-c or
- Hemdan, Magdy M.,Taha, Sherif M.,Gabr, Adel M.,Elkady, Mohamed Y.
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experimental part
p. 102 - 105
(2010/06/19)
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- Phtalazin derivatives and their use as pesticides
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The invention provides compounds of formula: wherein the symbols are as defined in the description, which possess utility as pesticides (e.g. herbicides and insecticides).
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- ALKYLATION OF 1-THIOXO-2-PHENYL-4-ARYL-1,2-DIHYDROPHTHALAZINES BY TRIETHYLOXONIUM TETRAFLUOROBORATE
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1-Thioxo-2-phenyl-4-aryl-1,2-dihydrophthalazines are alkylated by triethyloxonium tetrafluoroborate exclusively at the thiocarbonyl group with the formation of the salts of heteroaromatic ions.Hydrolysis of the latters lead to 1-oxo-2-phenyl-4-aryl-1,2-di
- Oparin, D. A.,Yakovlev, S. V.,Pavlova, L. A.
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p. 843 - 846
(2007/10/02)
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- ALKYLATION OF 1-0X0-2-PHENYL(METHYL)-4-ARYL(METHYL)-1,2-DIHYDROPHTHALAZINES WITH TRIETHYLOXONIUM FLUOROBORATE
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1-Oxo-2-phenyl-4-aryl-1,2-dihydrophthalazines are alkylated by triethyloxonium fluoroborate at the N3 nitrogen atom, forming corresponding 1-oxo-1,2-dihydrophthalazinium tetrafluoroborates.Under the same conditions 1-oxo-2-methyl-4-phenyl(methy
- Volynets, N. F.,Samartseva, I. V.,Khramova, I. V.,Pavlova, L. A.
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p. 1342 - 1346
(2007/10/02)
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- 1-HYDROXY-1-ARYL-2,4-DIPHENYLDIHYDROPHTHALAZINES. SYNTHESIS AND PROPERTIES
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A series of 1-hydroxy-1-aryl-2,4-diphenyldihydrophthalazines, which exhibit the characteristics of pseudo bases, were obtained by the action of arylmagnesium halides on 1-oxo-2,4-diphenylphthalazine. 1-Aryl-2,4-diphenylphthalazinium perchlorates and tetra
- L'vova, N. V.,Samartseva, I. V.,Pavlova, L. A.
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p. 1998 - 2003
(2007/10/02)
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