36503-83-0

Usage

Uses

Used in Organic Synthesis:
2,4-diphenylphthalazin-1(2H)-one is used as a reagent or intermediate in organic synthesis for its ability to facilitate various chemical reactions, contributing to the creation of a wide array of organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,4-diphenylphthalazin-1(2H)-one is used as a compound of interest in drug discovery for its potential to inhibit the growth of cancer cells. Its unique structure allows it to interact with biological targets, making it a candidate for further research into its therapeutic applications.
Used in Chemical Research:
2,4-diphenylphthalazin-1(2H)-one is utilized in chemical research to explore its properties and potential applications. Its study can lead to a better understanding of its reactivity, stability, and how it can be modified or combined with other compounds to achieve desired outcomes in various chemical processes.

Upstream product

• 85-52-9 2-Benzoylbenzoic acid 
• 100-63-0 phenylhydrazine 
• 606-28-0 methyl o-benzoylbenzoate 
• 85-44-9 phthalic anhydride 
• 71-43-2 benzene 
• 15226-74-1 dicobalt octacarbonyl 
• 13047-06-8 o-bromobenzophenone 
• 59-88-1 phenylhydrazine hydrochloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 59142-47-1 (2-bromophenyl)phenylmethanol 
• 13939-06-5 molybdenum hexacarbonyl 
• 574-61-8 benzophenone N-phenylhydrazone 
• 108-86-1 bromobenzene 
• 5004-45-5 4-phenyl-2H-phthalazin-1-one 

Downstream Products

• 77474-70-5 1-(4-Chloro-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 94637-22-6 1-methyl-2,4-diphenylphthalazinium iodide 
• 6092-09-7 1,2,4-triphenyl-1,2-dihydro-phthalazin-1-ol 
• 77474-67-0 1-(4-Methoxy-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 343808-17-3 1-(2-Methoxy-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 77474-66-9 2,4-diphenyl-1-p-tolyl-1,2-dihydro-phthalazin-1-ol 
• 77474-71-6 1-(4-Bromo-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 77474-69-2 1-(4-Ethoxy-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 77474-73-8 2,4-Diphenyl-1-(4-trifluoromethyl-phenyl)-1,2-dihydro-phthalazin-1-ol 
• 77474-72-7 1-(4-Fluoro-phenyl)-2,4-diphenyl-1,2-dihydro-phthalazin-1-ol 
• 57709-74-7 2,4-Diphenyl-1,2-dihydrophthalazine 
• 111585-59-2 1-thioxo-2,4-diphenyl-1,2-dihydrophthalazine 
• 85730-22-9 1,2-Dihydro-2,4-diphenyl-1-ethoxyphthalazine 
• 85730-21-8 2,4-Diphenyl-1,2-dihydrophthalazin-1-ol 

Relevant academic research and scientific papers

TOLL-LIKE RECEPTOR 8 (TLR8)-SPECIFIC ANTAGONISTS AND METHODS OF MAKING AND USES THEREOF

Toll-like receptor 8 (TLR8)-specific inhibitors and methods of using the same in individuals having an autoimmune disease or an inflammatory disorder.

Palladium-Catalyzed Acylation Reactions: A One-Pot Diversified Synthesis of Phthalazines, Phthalazinones and Benzoxazinones

A sequential one-pot strategy for the diversified synthesis of phthalazines, phthalazinones and benzoxazinones was presented. This strategy proceeds through [Pd]-catalyzed acylation and nucleophilic cyclocondensation with dinucleophilic reagents. This process was based on direct coupling with simple bench-top aldehydes without the assistance of directing group and without activating the carbonyl group. The process is highly advantageous because it employs simple nitrogen-based nucleophiles, and non-toxic and readily accessible aldehydes as the carbonyl source. Most importantly, the strategy was applied to the one-pot synthesis of PDE-4 inhibitor.

Palladium-Catalyzed Carbonylative Synthesis of 3-Methyleneisoindolin-1-ones from Ketimines with Hexacarbonylmolybdenum(0) as the Carbon Monoxide Source

An interesting procedure for the palladium-catalyzed carbonylative synthesis of 3-methyleneisoindolin-1-ones from ketimines was established. By using Mo(CO)6 (0.3 equiv.) as the solid CO source and through C(sp2)?H bond activation, t

Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source

A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO) 8 as carbonyl source making it rea

Ultrasound-promoted regio and chemoselective synthesis of pyridazinones and phthalazinones catalyzed by ionic liquid [bmim]Br/AlCl3

The first ultrasound-promoted multicomponent synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides and ArNHNH2 in the presence of an efficient recyclable catalyst, [bmim]Br/AlCl3, in high yield and short reaction time is reported.

An efficient one-pot synthesis of pyridazinones and phthalazinones using HY-zeolite

Figure represented. The first one-pot synthesis of pyridazinones and phthalazinones from arenes, cyclic anhydrides, and ArNHNH2 in the presence of efficient recyclable heterogeneous catalyst, HY-zeolite, in high yield and short reaction time is reported.

An efficient chemo- and regioselective three-component synthesis of pyridazinones and phthalazinones using activated KSF

The first three-component and regioselective synthesis of pyridazinones and phthalazinones from arenes, anhydrides and ArNHNH2 in the presence of efficient recyclable heterogeneous catalyst, montmorillonite-KSF, in high yield and short reaction time is reported.

Hydrazine derivatives and o-benzoylbenzoic acid as a source of phthalazines with their antimicrobial activities

Starting from 2-benzoylbenzoic acid (1) and prototype hydrazine itself or some of its simple congeners produce phthalazin-1(2H)-one derivatives 2a-d. Reactions of 2 with P2S5 or POCl3 gave their thione derivatives 3a-c or

Phtalazin derivatives and their use as pesticides

The invention provides compounds of formula: wherein the symbols are as defined in the description, which possess utility as pesticides (e.g. herbicides and insecticides).

ALKYLATION OF 1-THIOXO-2-PHENYL-4-ARYL-1,2-DIHYDROPHTHALAZINES BY TRIETHYLOXONIUM TETRAFLUOROBORATE

1-Thioxo-2-phenyl-4-aryl-1,2-dihydrophthalazines are alkylated by triethyloxonium tetrafluoroborate exclusively at the thiocarbonyl group with the formation of the salts of heteroaromatic ions.Hydrolysis of the latters lead to 1-oxo-2-phenyl-4-aryl-1,2-di