36626-29-6

Basic information

• Product Name: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE
• Synonyms: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE;(2-Carboxyethyl)tripheylphosphonium chloride;Nsc165227
• CAS NO: 36626-29-6
• Molecular Formula: C₂₁H₂₀O₂P*Cl
• Molecular Weight: 370.81
• Product Categories: Phosphorylating and Phosphitylating Agents
• Mol File: 36626-29-6.mol

Chemical Properties

• Melting Point: 197-201°C
• Appearance: white solid
• Storage Temp.: Refrigerator
• Solubility: Soluble in dimethyl sulfoxide and methanol.
• CAS DataBase Reference: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(36626-29-6)
• EPA Substance Registry System: (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE(36626-29-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 36626-29-6(Hazardous Substances Data)

Usage

Uses

Used in Organic Chemistry:
(2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE is used as a reagent for [Wittig olefinations] for [introduction of a carboxylic acid]. This application is particularly relevant in the synthesis of complex organic molecules, where the introduction of a carboxylic acid group is required.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE is used as a key intermediate in the synthesis of various drug molecules. Its ability to introduce a carboxylic acid group during Wittig olefinations makes it a valuable tool for the development of new pharmaceutical compounds with specific therapeutic properties.
Used in Material Science:
(2-CARBOXYETHYL)TRIPHENYLPHOSPHONIUM CHLORIDE is also used in the field of material science for the development of novel materials with unique properties. Its role in the synthesis of complex organic compounds can lead to the creation of new materials with enhanced characteristics, such as improved strength, flexibility, or chemical resistance.

InChI:InChI=1/C21H19O2P.ClH/c22-21(23)16-17-24(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20;/h1-15H,16-17H2;1H

Upstream product

• 906-65-0 3-(triphenyl-λ-phosphanylidene)dihydrofuran-2,5-dione 
• 60633-18-3 (3-carboxy-propyl)triphenylphosphonium chloride 
• 565-64-0 2,3-dichloropropanoic acid 
• 603-35-0 triphenylphosphine 

Downstream Products

• 127404-69-7 (E)-4-(4-cyanophenyl)but-3-enoic acid 
• 116237-15-1 (E)-4-((2R,4S,5R)-5-Hydroxy-2-phenyl-[1,3]dioxan-4-yl)-but-3-enoic acid 
• 463328-47-4 8-phenyl-3,5,7-octatrienoic acid 
• 192987-41-0 4-[1-(1-hydroxy-5-methyl-1,2,3,4-tetrahydronaphthyl)]-N-(triphenylmethyl)imidazole 
• 859809-70-4 4-o-tolyl-butyryl chloride 
• 6943-79-9 4-(2-methylphenyl)butanoic acid 
• 6939-35-1 5-methyl-1-tetralone 
• 83655-42-9 (E)-4-(2,5-dimethoxyphenyl)but-3-enoic acid 
• 51114-95-5 (E)-4-(3’,5’-dimethoxyphenyl)but-3-enoic acid 
• 192987-39-6 4-(2-methylphenyl)-3-butenoic acid 
• 112930-58-2 (E)-3-(6,11-dihydrodibenzothiepin-11-ylidene)propionic acid 
• 127404-81-3 (E)-4-(4-(methoxycarbonyl)phenyl)but-3-enoic acid 
• 127404-77-7 (E)-4-(3,4-dichlorophenyl)but-3-enoic acid 
• 127404-68-6 (E)-4-(4-(methylthio)phenyl)but-3-enoic acid 

Relevant articles and documents

Reaction of 2,3-dihalopropionic acids and their derivatives with P- and N-nucleophiles

3-(Triphenylphosphoniochlorido)acrylic and 2,3-dichloropropionic acids react with triphenylphosphine to form 1,2-bis(triphenylphosphoniochlorido) ethane. Under analogous conditions, 2,3-dibromopropionic acid undergoes debromination followed by triphenylphosphine addition to give, after water treatment, 3-(triphenylphosphoniobromido)propionic acid. 2,3- Dihalopropionitriles react similarly, providing 3-(triphenylphosphoniohalido) propionitriles. The reaction of 2,3-dibromopropionamide with triphenylphosphine was performed to show that E-(triphenylphosphoniobromido)acrylic acid is capable, by contrast to what was reported previously, of reacting with triphenylphosphine. Pyridine forms with 2,3-dihalopropionic acids vinylpyridinium halides, while the reactions with aliphatic amines gives rise to dehydrohalogenation products.

Histone deacetylase inhibitors

Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, inclu

SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS

The present invention provides dibenzoxazepine compounds of Formula I: STR1 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

Novel Synthesis of ω-(Diphenylphosphinyl)alkylcarboxylic Acids from Triphenyl-ω-carboxyalkylphosphonium Salts

A novel method for the synthesis of triphenylphosphonium salts of the type (C6H5)3P+(CH2)nCO2H,X- (1: n=2,3; X=Cl; n=5,10,11; X=Br) from the corresponding ω-haloalkylcarboxylic acids and triphenylphosphine has been described.When members of 1 were treated with NaH/Me2SO/THF at room temperature under N2, the corresponding ω-(diphenylphosphinyl)alkylcarboxylic acids 2 (n=3,5,10,11) were isolated.The yields were good (62-75percent) for compounds with longer side chains (n=10,11).In one case (n=3), (C6H5)3P was isolated as a side product (yield 20percent).Attempts to prepare the Wittig reagents from 1 and the subsequent reaction with aldehydes (benzaldehyde and 9-anthraldehyde) failed to yield the expected alkenes.However, members of 2 were produced, and it was possible to recover >90percent of the unreacted 9-anthraldehyde.The structures of the compounds in the series 1 and 2 have been established via the spectral properties and elemental analyses.The 31P and 13C chemical shifts as well as C-P coupling constants have been evaluated and analyzed.A tentative mechanism has been proposed for the formation of 2 from 1.