565-64-0Relevant articles and documents
Synthesis method of DL-cysteine
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Paragraph 0020-0022, (2021/02/13)
The invention discloses a synthetic method of DLcysteine. The method comprises the following steps: by using acrylonitrile as a raw material, chlorinating to generate 2, 3dichloropropionitrile, hydrolyzing to generate corresponding acid, reacting the acid with thiourea to cyclize to generate 2-aminothiazoline-4-carboxylic acid, adding alkali sulfide to generate 2-mercaptothiazoline-4-carboxylic acid, and hydrolyzing to generate cysteine. The synthesis method provided by the invention has the advantages of short synthesis steps, mild preparation conditions, sufficient and cheap raw material sources and higher product yield.
Visible Light-Induced Oxidative Chlorination of Alkyl sp3 C-H Bonds with NaCl/Oxone at Room Temperature
Zhao, Mengdi,Lu, Wenjun
supporting information, p. 4560 - 4563 (2017/09/11)
A visible light-induced monochlorination of cyclohexane with sodium chloride (5:1) has been successfully accomplished to afford chlorocyclohexane in excellent yield by using Oxone as the oxidant in H2O/CF3CH2OH at room temperature. Other secondary and primary alkyl sp3 C-H bonds of cycloalkanes and functional branch/linear alkanes can also be chlorinated, respectively, under similar conditions. The selection of a suitable organic solvent is crucial in these efficient radical chlorinations of alkanes in two-phase solutions. It is studied further by the achievement of high chemoselectivity in the chlorination of the benzyl sp3 C-H bond or the aryl sp2 C-H bond of toluene.
Reaction of (α-halogenoalkyl)thiiranes with nucleophilic reagents I. Reaction with morpholine
Tomashevskii, A. A.,Sokolov, V. V.,Potekhin, A. A.
, p. 1610 - 1618 (2007/10/03)
By means of deuterated compounds it was established that (chloromethyl)thiirane reacts with morpholine by a mechanism involving initial opening of the thiirane ring followed by recyclization.In the case of (bromomethyl)thiirane direct substitution of the bromine begins to compete with this mechanism. 2-Methyl-2-(chloromethyl)thiirane, 2,2-dimethyl-3-(chloromethyl)thiirane, and the diastereomeric (1-chloroethyl)thiiranes were synthesized, and their reactivity toward morpholine was studied.