- Method for realizing continuous production of acyl chloride compound through immobilization of organic base catalyst
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The invention discloses a method for realizing continuous production of an acyl chloride compound through immobilization of an organic base catalyst, and belongs to the technical field of organic chemical industry. Amino, pyridine, acetamide and nicotinamide organic base silane coupling agents are used for treating a glass micro-channel reactor to immobilize an organic base catalyst; by taking 3, 5, 5-trimethyl hexanoic acid, adipic acid, trimethyl acetic acid, benzoic acid and terephthalic acid as raw materials, acylating chlorination reaction is carried out through a fixed bed micro-channel to generate corresponding 3, 5, 5-trimethyl hexanoyl chloride, adipoyl chloride, trimethyl acetyl chloride, benzoyl chloride and terephthaloyl chloride; the solvent(s) is/are one or more of methylbenzene, dichloromethane, dichloroethane, cyclohexane and tetrahydrofuran; the molar ratio of the carboxylic acid groups to the triphosgene is 3: (1-1.5); and the reaction temperature is 30-150 DEG C, the total feeding speed of the materials is 5-40 mL/min, and the reaction time is 2-16 min. The 3, 5, 5-trimethyl hexanoyl chloride, benzoyl chloride and adipoyl chloride are produced by the method disclosed by the invention, the repeated utilization of the catalyst is realized, the product purity is high, the production process is safe, and the environmental pollution is reduced.
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Paragraph 0051-0059
(2021/08/14)
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