A convenient and high yield method to prepare 4-hydroxypyroglutamic acids
RuO2/NaIO4 oxidation of N-Boc-4-silyloxy and 4-acetoxy proline methyl esters under ethyl acetate/water biphase condition gave N-Boc-4-silyloxy and 4-acetoxy pyroglutamic acid derivatives in high yields. Desilylation with TBAF afforded both cis- and trans-N-Boc-methyl-4-hydroxy pyroglutamates.
Zhang, Xiaojun,Schmitt, Aaron C.,Jiang, Wen
p. 5335 - 5338
(2007/10/03)
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