367966-46-9

Upstream product

• 367966-67-4 1-(tert-butyl) 2-methyl (2S,4S)-4-((tert-butyldimethylsilyl)oxy)-5-oxopyrrolidine-1,2-dicarboxylate 
• 604-44-4 4-chloronaphthalen-1-ol 
• 367966-73-2 methyl (4S)-cis-N-Boc-4-hydroxyl pyroglutamate 

Downstream Products

• 367966-54-9 (2S,4R)-5-Acetoxy-4-(4-chloro-naphthalen-1-yloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 367966-51-6 (2S,4R)-4-(4-Chloro-naphthalen-1-yloxy)-5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant academic research and scientific papers

A convenient and high yield method to prepare 4-hydroxypyroglutamic acids

RuO2/NaIO4 oxidation of N-Boc-4-silyloxy and 4-acetoxy proline methyl esters under ethyl acetate/water biphase condition gave N-Boc-4-silyloxy and 4-acetoxy pyroglutamic acid derivatives in high yields. Desilylation with TBAF afforded both cis- and trans-N-Boc-methyl-4-hydroxy pyroglutamates.